Evaluation of the Pulmonary Toxicity of a Fume Generated from a Nickel-, Copper-Based Electrode to be Used as a Substitute in Stainless Steel Welding

Details

• Alternative Title:
  Environ Health Insights
• Personal Author:
  Antonini, James M. ; Badding, Melissa A. ; Meighan, Terence G. ; Keane, Michael ; Leonard, Stephen S. ; Roberts, Jenny R.
• Description:
  Epidemiology has indicated a possible increase in lung cancer among stainless steel welders. Chromium (Cr) is a primary component of stainless steel welding fume. There is an initiative to develop alternative welding consumables [nickel (Ni)- and copper (Cu)-based alloys] that do not contain Cr. No study has been performed to evaluate the toxicity of fumes generated from Ni- and Cu-based consumables. Dose-response and time-course effects on lung toxicity of a Ni- and Cu-based welding fume (Ni-Cu WF) were examined using an in vivo and in vitro bioassay, and compared with two other well-characterized welding fumes. Even though only trace amounts of Cr were present, a persistent increase in lung injury and inflammation was observed for the Ni-Cu WF compared to the other fumes. The difference in response appears to be due to a direct cytotoxic effect by the Ni-Cu WF sample on lung macrophages as opposed to an elevated production of reactive oxygen species (ROS).
• Subjects:
  Chromium Copper Nickel Original Research Particulate Matter Pulmonary Toxicity Welding Fume
• Source:
  Environ Health Insights. 2014; 8(Suppl 1):11-20.
• Document Type:
  Journal Article
• Volume:
  8
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:c85c180f1c7be429550274d74426ebfe9987b843840a6c0d646bbf5c5b8c565b
• Download URL:
  https://stacks.cdc.gov/view/cdc/26073/cdc_26073_DS1.pdf
• File Type:
  [PDF - 870.67 KB ]