Building a Growing Genomic Repository For Maternal and Fetal Health Through the PING Consortium.

Details

• Alternative Title:
  Pediatric Research, 2025, v. 98, no. 2: Building a Growing Genomic Repository For Maternal and Fetal Health Through the PING Consortium.
• Journal Article:
  Pediatric Research
• Personal Author:
  Abdelmalek, Clara M. ; Singh, Shriya ; Fasil, Blain ; Horvath, Allison R. ; Mulkey, Sarah B. ; Curé, Carlos ; Campos, Maribel ; Cavalcanti, Denise P. ; Tong, Van T. ; Mercado, Marcela ; Daza, Marcela ; Benavides, Mónica Marcela ; Acosta, Jacqueline ; Gilboa, Suzanne ; Valencia, Diana ; Sancken, Christina L. ; Newton, Suzanne ; Scalabrin, Deolinda M. F. ; Mussi-Pinhata, Marisa M. ; Vasconcelos, Zilton ; Chakhtoura, Nahida ; Moye, Jack ; Leslie, Elizabeth J. ; Bulas, Dorothy ; Vezina, Gilbert ; Marques, Fernanda J. P. ; Leyser, Marcio ; Del Campo, Miguel ; Vilain, Eric ; DeBiasi, Roberta L. ; Wang, Tongguang ; Nath, Avindra ; Haydar, Tarik ; Muenke, Max ; Mansour, Tamer A. ; du Plessis, Adre J. ; Murray, Jeffrey C. ; Cordero, José F. ; Kousa, Youssef A.
  More +
• Description:
  Prenatally transmitted viruses can cause severe damage to the developing brain. There is unexplained variability in prenatal brain injury and postnatal neurodevelopmental outcomes, suggesting disease modifiers. Of note, prenatal Zika infection can cause a spectrum of neurodevelopmental disorders, including congenital Zika syndrome. Currently, there is no preventative treatment or cure. The Prenatal Infection and Neurodevelopmental Genetics (PING) Consortium aims to identify modulators of brain injury and adverse neurodevelopmental outcomes for Zika and other prenatal viral infections. ; The Consortium pools information from eight multi-site studies conducted at 23 research centers in six countries to build a growing clinical and genomic repository, which is being mined for modifiers of virally induced brain injury. Partners include Children's National Hospital (USA), Instituto Nacional de Salud (Colombia), the Natural History of Zika Virus Infection in Gestation program (Brazil), Zika Instituto Fernandes Figueira (Brazil), the Centers for Disease Control and Prevention, and the National Institutes of Health. ; We have enrolled 4102 mothers and 3877 infants with 3063 biological samples and clinical data covering over 80 phenotypic fields and 5000 variables. Thus far, we have performed whole exome sequencing on 1226 participants. ; Here, we present the Consortium's formation and overarching study design. ; The PING Consortium brings together investigators and institutions to determine the causes of virally induced brain injury and neurological deficits. The clinical and genomic repository, with data from over 8000 patients, will serve as a foundation for a variety of basic and clinical studies.
• Content Notes:
  Author manuscript
• Subjects:
  • Adult
  • Female
  • Humans
  • Infant, Newborn
  • Male
  • Pregnancy
  • Biological Specimen Banks
  • Brain Injuries
  • Databases, Genetic
  • Epidemiologic Research Design
  More +
• Source:
  Pediatric Research, 2025, v. 98, no. 2
• DOI:
  https://doi.org/10.1038/s41390-024-03793-1
• ISSN:
  0031-3998 ; 1530-0447
• Pubmed ID:
  PMC12222536
• Pubmed Central ID:
  39753885
• Document Type:
  Text
• Funding:
  K08 NS119882/NS/NINDS NIH HHSUnited States/ ; L40 HD102847/HD/NICHD NIH HHSUnited States/ ; R01 HD102445/HD/NICHD NIH HHSUnited States/ ; R21 DE027235/DE/NIDCR NIH HHSUnited States/ ; CC999999/ImCDC/Intramural CDC HHSUnited States/
• Genre:
  Journal Article
• Place as Subject:
  Brazil ; Colombia ; United States
• Pages in Document:
  519-531 (31 pdf pages)
• Volume:
  98
• Issue:
  2
• Download URL:
  https://stacks.cdc.gov/view/cdc/260369/cdc_260369_DS1.pdf
• File Type:
  [PDF - 1.35 MB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:fe754837dc2d275e2d37df87d1533af3167f33e7a95070c9f1aae8d2c02e3a5baea90273c96ec9c46dc2b8358526ab3620725bea3d8ac31d41de58daf40b157d