Ad Libitum Drinking Does Not Mitigate Acute Kidney Injury Risk nor Elevations in Markers of Oxidative Stress and Inflammation During Simulated Occupational Heat Stress

Details

• Personal Author:
  Tourula, Erica ; Hite, M. Jo ; Heikkinen, Molly E. ; Hess, Hayden W. ; Amorim, Fabiano T. ; Mickleborough, Timothy D. ; Johnson, Blair D. ; Hostler, David ; Schlader, Zachary J.
• Description:
  This study tested the hypothesis that ad libitum fluid intake during a 2-h occupational heat stress simulation attenuates increases in renal oxidative stress, inflammation, and acute kidney injury (AKI) risk compared with fluid restriction. Thirteen healthy adults (5 women) completed two 2-h occupational heat stress simulations consisting of eight circuits of treadmill walking and rowing exercise in a wet bulb globe temperature of 33.1 +/- 0.2 degrees C. In the drinking trial (Drink), participants were provided 237 mL of a noncaloric sport drink every 15 min and drank ad libitum. In the fluid restriction trial (No Drink), no fluid was provided. Urine and blood samples were analyzed for markers of oxidative stress (thioredoxin-1, TRX-1), inflammation (monocyte chemotactic protein-1, MCP-1), and AKI risk ([IGFBP7·TIMP-2]). During Drink, ad libitum fluid intake was 1,394 +/- 316 mL, and reductions in body weight were greater in No Drink (1.3 +/- 0.8% vs. 2.8 +/- 0.9%, P < 0.001). Peak core temperature was not different between Drink (38.5 +/- 0.4 degrees C) and No Drink [38.6 +/- 0.4 degrees C, mean difference (upper, lower CI): 0.1 (0.4, -0.1) degrees C; P = 0.346]. Urine, but not serum TRX-1 (P = 0.254), was elevated at postrecovery and recovery (P < 0.001) but not different between trials (P = 0.743). Serum and urine MCP-1 were elevated at postrecovery and recovery (P < 0.001) but not different between trials (P = 0.407). Urine [IGFBP7·TIMP-2] was elevated at postrecovery and recovery (P < 0.001) but not different between trials (P = 0.096). Ad libitum fluid intake during a 2-h occupational heat stress simulation does not modify biomarkers of systemic and renal oxidative stress and inflammation, nor AKI risk, compared with when fluid is restricted.
• Subjects:
  Heat Stress Disorders Inflammation Kidney Occupational Health Oxidative Stress Safety
• Keywords:
  Author Keywords: Dehydration; Hyperthermia; Kidney Function; Work-related Heat Stress Heat Stress; Temperature Effects; Kidney Function; Oxidative Stress; Fluids; Dehydration; Biomarkers; Hyperthermia;
• ISSN:
  1931-857X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Indiana ; New York ; New Mexico ; Chicago Region [OSHA] ; New York City Region [OSHA] ; Dallas Region [OSHA]
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  18 pdf pages
• Volume:
  330
• NIOSHTIC Number:
  nn:20071168
• Citation:
  Am J Physiol Renal Physiol 2026 Jan; 330(1):F71-F88
• Email:
  zschlade@iu.edu
• Federal Fiscal Year:
  2026
• Performing Organization:
  Indiana University, Bloomington
• Peer Reviewed:
  True
• Start Date:
  20190901
• Source Full Name:
  American Journal of Physiology: Renal Physiology
• End Date:
  20240831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d4624943682dd74e7ad2d2df4879429a36a6d46b101ba95502c5569c974bbf8e1f249999169d4c0e50e9c9933186c9a8c1598ce3be2a2f16d7980eec18c849bd
• Download URL:
  https://stacks.cdc.gov/view/cdc/257934/cdc_257934_DS1.pdf
• File Type:
  [PDF - 4.35 MB ]