The primary host of LCMV is the common house mouse (Mus musculus). LCMV is not normally found in pet rodents, such as mice, hamsters, gerbils, and guinea pigs. However, pet rodents can become infected after being in contact with wild house mice in breeding facilities, pet stores, or homes. People have become infected from contact with LCMV-infected mice and hamsters.

Humans can develop LCMV infection from exposure to urine, droppings, saliva, or nesting material of infected rodents. LCMV infection can also occur when these materials are inhaled or directly introduced into broken skin or into the nose, eyes, or mouth, and possibly by a bite from an infected animal.

Stephen B. Thacker CDC Library collection