Interim guidance for the removal of quarantine orders and the euthanasia of animals affected by the monkeypox outbreak
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Interim guidance for the removal of quarantine orders and the euthanasia of animals affected by the monkeypox outbreak

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    Monday, June 30, 2003, 21:45 EDT (9:45 PMEDT)


    The Centers for Disease Control and Prevention (CDC) has been working closely with several state and local health departments and other partners to investigate cases of monkeypox virus infections among persons who had direct or close contact with ill prairie dogs. Exposures of interest to these ill animals occurred after April 15, 2003.

    Monkeypox is a rare viral disease that typically occurs among animals and humans in central and west Africa. In humans, the illness produces a blister-like rash similar to that of smallpox. Time from contact with a sick animal to the beginning of fever in a person is usually about 12 days. During the current outbreak of monkeypox in the United States, most infected persons have had illness that was relatively mild to moderate in severity, and there have been no deaths. However, the disease can be severe, and in Africa about 1% to 10% of human cases are fatal. (For additional information about monkeypox, see

    This document provides interim guidance for state and federal officials who have issued quarantine orders restricting the movement of animals that may have been exposed to monkeypox virus.

    During the emergency response to monkeypox, CDC and the Food and Drug Administration issued a jo in t order banning the importation of African rodents and the sale and movement of involved animals (see: ). The joint order remains in effect regardless of the actions taken pursuant to this guidance. In addition, CDC recommended that states place quarantines or hold orders on 1) premises with infected animals (Infected Premises); 2) premises that received African rodents from a particular shipment (from Ghana to Texas on April 9, 2003) of imported animals that was identified during the traceback investigation (Premises Receiving Imported African Rodents); and 3) premises that received prairie dogs from a holding facility w here wild or exotic mammalian pets with suspect, probable, or confirmed monkeypox have been reported.

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