Supplemental information : Novel coronavirus linked to Severe Acute Respiratory Syndrome
Advanced Search
Select up to three search categories and corresponding keywords using the fields to the right. Refer to the Help section for more detailed instructions.

Search our Collections & Repository

For very narrow results

When looking for a specific result

Best used for discovery & interchangable words

Recommended to be used in conjunction with other fields

Dates

to

Document Data
Library
People
Clear All
Clear All

For additional assistance using the Custom Query please check out our Help Page

i

Supplemental information : Novel coronavirus linked to Severe Acute Respiratory Syndrome

Filetype[PDF-751.74 KB]


English
Details You May Also Like

Details:

  • Corporate Authors:
  • Description:
    Monday, March 24, 2003, 23:10 EST (11:10 PM EST)

    CDCHAN -00128-03-03-24-UPD-N

    The Centers for Disease Control and Prevention announced today that laboratory analysis has identified a previously unrecognized coronavirus in clinical specimens from patients with severe acute respiratory syndrome (SARS). Coronaviruses are a com m on cause of mild to moderate upper-respiratory illness in humans and are associated with respiratory, gastrointestinal, liver, and neurologic disease in several animal species. Since late February 2003, CDC has been working with the World Health Organization (WHO ), international partners at laboratory centers, and ministries of health in an investigation of SARS. As of March 24, a total of 456 cases of SARS and 17 deaths had been reported worldwide, according to WHO.

    The new coronavirus was isolated from clinical specimens of two patients with SARS, cultured in Vero E6 cells, and then characterized by several laboratory methods. Electron microscopy showed that the agent has the distinctive shape and appearance of coronaviruses. Testing of multiple sera from each of three patients by indirect fluorescent antibody (IFA) tests showed that all three went from being negative to positive for the new coronavirus; a single convalescent-phase specimen from a fourth patient was also IFA positive. Polymerase chain reaction analysis of other specimens (including nasal and oral swabs and lung tissue) revealed the presence of coronavirus in at least five patients, including two with IFA-positive results. Other serologic tests demonstrated that the new agent reacts with antisera to one of the three known coronavirus serogroups, but sequence analysis suggests that it is distinct from the known coronaviruses.

    CDC officials emphasized that the laboratory results announced today are preliminary and do not provide conclusive evidence that the new agent is the cause of SARS. Several laboratories collaborating in the WHO-led investigation had previously reported the isolation of a different virus -human metapneumovirus- from patients with SARS. There is insufficient information at this time to determine what role the new coronavirus or metapneumovirus has in the cause of SARS.

  • Subjects:
  • Series:
    HAN ; 128
  • Document Type:
    HAN Health Advisory
  • Place as Subject:
    United States
  • Pages in Document:
    1 unnumbered page
  • Volume:
    128
  • Collection(s):
  • Main Document Checksum:
  • Download URL:
  • File Type:

Supporting Files

  • No Additional Files
More +

You May Also Like

Checkout today's featured content at stacks.cdc.gov