Use of Ciprofloxacin or Doxycycline for Postexposure Prophylaxis for Prevention of Inhalational Anthrax [Wednesday, October 31, 2001, 13:45 EST (1:45 PM EST)]

Details

• Corporate Authors:
  Centers for Disease Control and Prevention (U.S.). Health Alert Network (HAN)
• Description:
  Wednesday, October 31, 2001, 13:45 EST (1:45 PM EST) ; CDCHAN-00049-2001-10-31-ADV-N ; Interim recommendations, MMWR 50(no 41):893 Oct 19,2001, for postexposure prophylaxis to prevent inhalational anthrax after exposure to B. anthracis spores recommend ciprofloxacin or doxycycline as initial therapy in situations associated with the current bioterrorist attack in the United States. ; EFFECTIVENESS: There is no evidence which demonstrates that ciprofloxacin is more or less effective than doxycycline for postexposure prophylaxis for prevention of infection with B. anthracis ; RESISTANCE: Widespread use of any antibiotic will promote resistance. Many common pathogens are already resistant to tetracyclines such as doxycycline. However, ciprofloxacin resistance is not yet common in these same organisms. To preserve the effectiveness of ciprofloxacin against other infections, use of doxycycline for prevention of B. anthracis infection is reasonable. Ciprofloxacin is an effective antimicrobial for a variety of other bacterial infections. Thus, the wide use of this drug in thousands of individuals may lead to increased resistance of other bacterial pathogens to ciprofloxacin and other fluroquinolones, and limit the usefulness of these agents. ; SIDE EFFECTS: On the basis of side-effect profiles (see below), the history of reactions, or the clinical setting, either doxycycline or ciprofloxacin may be preferable for an individual patient. ; Event Type: anthrax terrorism event ; Context: countermeasures/therapeutics ; Event Type: Man-made ; Agent Type: bacteria ; Specify Agent (Name): anthrax ; International: no ; Intentional/Unintentional: intentional
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• Content Notes:
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• Subjects:
  • Anthrax
  • Anti-Bacterial Agents/therapeutic use
  • Antibiotic Prophylaxis
  • Bacillus anthracis
  • Ciprofloxacin/therapeutic use
  • Doxycycline/therapeutic use
  • Occupational Exposure
  • Post-Exposure Prophylaxis
  • Respiratory Tract Infections
• Keywords:
  • Health Alert Network
  • HAN
• Source:
  HAN ; 049
• Series:
  Health Alert Network
• Subseries:
  CDC Health Advisory
• Document Type:
  Text
• Genre:
  Alert
• Place as Subject:
  United States
• Rights:
  Public Domain
• Pages in Document:
  4 unnumbered pages
• Issue:
  00049
• Download URL:
  https://stacks.cdc.gov/view/cdc/24962/cdc_24962_DS1.pdf
• File Type:
  [PDF - 1.12 MB]
• Collection(s):
  Health Alert Network (HAN)
• Main Document Checksum:
  urn:sha-512:f2b8402cf8988d5f994cf65bc68662b3c9a32d6e4119a5387ab031bba32828fdc49db59379f78f527e5b37744e2e7d6c133e19d39fa047a5c6a88d5c85de449c