Plasma p-tau181 shows stronger network association to Alzheimer's disease dementia than neurofilament light and total tau.

Details

• Personal Author:
  Ally M ; Alosco ML ; Ashton NJ ; Au R ; Blennow K ; Brekke B ; Budson AE ; Frank B ; Goldstein LE ; Jun GR ; Karikari TK ; Killiany R ; Kowall NW ; Martin B ; McKee AC ; Mez J ; O'Connor MK ; Palmisano JN ; Qiu WQ ; Simkina I ; Stein TD ; Steinberg EG ; Stern RA ; Sugarman MA ; Tripodis Y ; Turk KW ; Zetterberg H
• Description:
  Introduction: We examined the ability of plasma hyperphosphorylated tau (p-tau)181 to detect cognitive impairment due to Alzheimer's disease (AD) independently and in combination with plasma total tau (t-tau) and neurofilament light (NfL). Methods: Plasma samples were analyzed using the Simoa platform for 235 participants with normal cognition (NC), 181 with mild cognitive impairment due to AD (MCI), and 153 with AD dementia. Statistical approaches included multinomial regression and Gaussian graphical models (GGMs) to assess a network of plasma biomarkers, neuropsychological tests, and demographic variables. Results: Plasma p-tau181 discriminated AD dementia from NC, but not MCI, and correlated with dementia severity and worse neuropsychological test performance. Plasma NfL similarly discriminated diagnostic groups. Unlike plasma NfL or t-tau, p-tau181 had a direct association with cognitive diagnosis in a bootstrapped GGM. Discussion: These results support plasma p-tau181 for the detection of AD dementia and the use of blood-based biomarkers for optimal disease detection. [Description provided by NIOSH]
• Subjects:
  Biomarkers Mental Health Nervous System Occupational Health Safety
• Keywords:
  Author Keywords: Alzheimer's Disease; Network Analysis; Neuropsychology; P-tau; Plasma Biomarkers Brain Function; Proteins; Neurological Diseases; Cognitive Function; Psychological Effects; Biomarkers; Blood Plasma;
• ISSN:
  1552-5260
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  18
• Issue:
  8
• NIOSHTIC Number:
  nn:20065895
• Citation:
  Alzheimers Dement 2022 Aug; 18(8):1523-1536
• Contact Point Address:
  Michael L. Alosco, Boston University Alzheimer's Disease Center and CTE Center, Boston University School of Medicine, 72 E. Concord Street, Suite B7800, Boston, MA 02118, USA
• Email:
  malosco@bu.edu
• Federal Fiscal Year:
  2022
• Performing Organization:
  Boston University Medical Campus
• Peer Reviewed:
  True
• Start Date:
  20180930
• Source Full Name:
  Alzheimer's & Dementia
• End Date:
  20220929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:2b86a7edaa347f6314d7fb83f1ce661a917102f747231cc89848e822189693a7fd1b8e4e2de86f83c1c1b582058b67560a85d1eda1f582bf821dd91a918be3e4
• Download URL:
  https://stacks.cdc.gov/view/cdc/249591/cdc_249591_DS1.pdf
• File Type:
  [PDF - 1.08 MB ]