Preventing Parkinson's disease: an environmental agenda.

Details

• Personal Author:
  De Miranda BR ; Dorsey ER ; Goldman SM ; Greenamyre JT ; Miller GW
• Description:
  Fueled by aging populations and continued environmental contamination, the global burden of Parkinson's disease (PD) is increasing. The disease, or more appropriately diseases, have multiple environmental and genetic influences but no approved disease modifying therapy. Additionally, efforts to prevent this debilitating disease have been limited. As numerous environmental contaminants (e.g., pesticides, metals, industrial chemicals) are implicated in PD, disease prevention is possible. To reduce the burden of PD, we have compiled preclinical and clinical research priorities that highlight both disease prediction and primary prevention. Though not exhaustive, the "PD prevention agenda" builds upon many years of research by our colleagues and proposes next steps through the lens of modifiable risk factors. The agenda identifies ten specific areas of further inquiry and considers the funding and policy changes that will be necessary to help prevent the world's fastest growing brain disease. [Description provided by NIOSH]
• Subjects:
  Aging Environmental Pollution Genetics Insecticides Manufacturing And Industrial Facilities Metals Occupational Health Risk Assessment Risk Factors Safety
• Keywords:
  Author Keywords: Parkinson's Disease; Air Pollution; Chlorinated Solvents; Clinical Research; Environment; Metals; Pesticides; Preclinical Research Parkinsons Disease; Aging; Environmental Contamination; Genetics; Pesticides; Metals; Industrial Hazards; Chemicals; Disease Prevention; Risk Factors; Brain Disorders; Diseases;
• ISSN:
  1877-7171
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Alabama ; California ; New York ; OSHA Region 2 ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 9 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  45-68
• Volume:
  12
• Issue:
  1
• NIOSHTIC Number:
  nn:20065092
• Citation:
  J Parkinsons Dis 2022 Jan; 12(1):45-68
• Contact Point Address:
  Briana De Miranda, PhD, University of Alabama at Birmingham, 1719 6th Avenue South, CIRC 560, Birmingham, AL 35294
• Email:
  BrianaDeMiranda@UABMC.edu
• Federal Fiscal Year:
  2022
• Performing Organization:
  University of California, Berkeley
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Journal of Parkinson's Disease
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e4caf40e98e13edecdaa8773ad6083962f3f56fa1df31ee289a8746f3836ede85aa6baaba6e0c345da8f06238aa81c25bbec838d149c09863c675ed5611d33e6
• Download URL:
  https://stacks.cdc.gov/view/cdc/249327/cdc_249327_DS1.pdf
• File Type:
  [PDF - 891.68 KB ]