PM2.5 metal constituent exposure and stillbirth risk in Harris County, Texas.

Details

• Personal Author:
  Chan W ; Han I ; Rammah A ; Symanski, Elaine ; Whitworth KW
• Description:
  There is limited evidence on the role of exposure to chemical constituents of fine particulate matter (PM2.5) in risk for stillbirth. Thus, we conducted a case-control study in Harris County, Texas between 2008 and 2013, utilizing a 6:1 ratio of controls to individually matched cases. We linked birth and fetal death records with PM2.5 data from a single air monitoring station and estimated maternal exposures to metal constituents of PM2.5 over the risk period (defined by the gestational length of each case). We applied conditional logistic regression and modeled air pollutant exposures as continuous variables. We observed null associations for most metal constituents (Al, Cr, Cu, Fe, Pb, Mn, Ni, Se and Ti). However, we observed a modest increase in risk for stillbirth (adjusted odds ratio (OR) = 1.11, 95% confidence interval (CI): 1.02, 1.20) associated with a 0.007 µg/m3 interquartile range (IQR) increase in exposure to zinc (Zn) PM2.5. This study adds to the scarce literature evaluating associations between PM2.5 metal constituents and stillbirth and points to the need for further research in this area. [Description provided by NIOSH]
• Subjects:
  Metals Mortality Occupational Health Particulate Matter Pregnancy Safety
• Keywords:
  Author Keywords: Stillbirth; PM2.5; Metals; Speciated; Maternal Exposure Particulates; Metals; Pregnancy; Prenatal Exposure; Mortality Data; Case Control Studies; Death Certificates;
• ISSN:
  0013-9351
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 6 ; Texas
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  176
• NIOSHTIC Number:
  nn:20064775
• Citation:
  Environ Res 2019 Sep; 176:108516
• Contact Point Address:
  Elaine Symanski, Epidemiology, Human Genetics and Environmental Sciences, The University of Texas Health Science Center at Houston (UTHealth) School of Public Health, 1200 Herman Pressler Street, Suite W-1030, Houston, TX, 77030, USA
• Email:
  elaine.symanski@uth.tmc.edu
• CAS Registry Number:
  Aluminum (CAS RN 7429-90-5) ; Chromium (CAS RN 7440-47-3) ; Copper (CAS RN 7440-50-8) ; Iron (CAS RN 7439-89-6) ; Lead (CAS RN 7439-92-1) ; Manganese (CAS RN 7439-96-5) ; Nickel (CAS RN 7440-02-0) ; Selenium (CAS RN 7782-49-2) ; Titanium (CAS RN 7440-32-6) ; Zinc (CAS RN 7440-66-6)
• Federal Fiscal Year:
  2019
• Performing Organization:
  University of Texas Health Science Center, Houston
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Environmental Research
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:99c2f75348489efea8f00a0760f361ef56cca774c22d0fbe5974c6690ab0f5eb54306792fbedc7e2099af722db7d1ba8415fabbb2b72570c8150a0594976d0d8
• Download URL:
  https://stacks.cdc.gov/view/cdc/249231/cdc_249231_DS1.pdf
• File Type:
  [PDF - 177.95 KB ]