HEPA filtration improves asthma control in children exposed to traffic-related airborne particles.

Details

• Personal Author:
  Bernstein DI ; Cox J ; Indugula R ; James C ; Jandarov R ; Newman N ; Reponen T ; Ryan P ; Wolfe C
• Description:
  Traffic-related airborne particles are associated with asthma morbidity. The aim of this study was to assess the impact of a high-efficiency particulate air (HEPA) filtration on the concentrations of traffic particles and the resultant effect on children with asthma. Forty-three children with asthma were enrolled in this double-blind, placebo-controlled crossover design. A HEPA air cleaner or a placebo "dummy" was placed in participants' homes for four weeks, interrupted by a one-month washout period, before crossing over to the other treatment arm for four weeks. Air sampling and health outcomes, including asthma control (ACQ) and quality of life (AQLQ) measures, were completed prior to and at the end of each treatment arm. Indoor concentrations of traffic particles were significantly reduced with the HEPA treatment but not with the "dummy" treatment. In participants with poorly controlled asthma and lower quality of life at baseline, ACQ and AQLQ scores were significantly improved (1.3 to 0.9, P = .003 and 4.9 to 5.5, P = .02, respectively) following the HEPA treatment. In this study, HEPA filtration is associated with improved clinical outcomes and quality of life measures in children with uncontrolled asthma. [Description provided by NIOSH]
• Subjects:
  Air Pollution, Indoor Asthma Asthma, Occupational Environmental Exposure Occupational Health Particulate Matter Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Author Keywords: Asthma Control Questionnaire; Asthma Quality Of Life Questionnaire; Black Carbon; High-efficiency Particulate Air Filter; PM2.5 Indoor Environments; Indoor Air Pollution; Particulates; Environmental Exposure; Children; Respiratory Diseases; Asthma; HEPA Filters; High-efficiency Particulate Air Filters; Automotive Emissions;
• DOI:
  https://doi.org/10.1111/ina.12625
• ISSN:
  0905-6947
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  235-243
• Volume:
  30
• Issue:
  2
• NIOSHTIC Number:
  nn:20064992
• Citation:
  Indoor Air 2020 Mar; 30(2):235-243
• Contact Point Address:
  Tiina Reponen, Department of Environmental Health, University of Cincinnati, P.O. Box 670056, Cincinnati, OH, 45267-0056 USA
• Email:
  Tiina.Reponen@uc.edu
• CAS Registry Number:
  Carbon black (CAS RN 1333-86-4)
• Federal Fiscal Year:
  2020
• Performing Organization:
  University of Cincinnati
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Indoor Air
• End Date:
  20260630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:9c2956b9ac95c5c7fe37d0a026a3fb1291e8995454db2fb61e15ed2e7cbdefb47f7a1ceee1dfc3950917bf4fd2823a38c40825455a7edf7f1dc699e605fc4678
• Download URL:
  https://stacks.cdc.gov/view/cdc/248976/cdc_248976_DS1.pdf
• File Type:
  [PDF - 492.39 KB ]