Nightshift Work Before and During Pregnancy and Offspring Mental Health Disorders in Adolescence

Details

• Personal Author:
  Devore EE ; Eliassen H ; Missmer S ; Okereke O ; Schernhammer ES ; Strohmaier S ; Vetter C
• Description:
  Studies suggest that nightshift work induces epigenetic alterations and especially exposure surrounding pregnancy may lead to behavioral programming in the offspring. We investigated the association between maternal rotating nightshift work history before pregnancy (4,044 mothers, 4,813 children) and nightshift work during pregnancy (545 mother-child pairs) and offspring mental health outcomes through adolescence among children enrolled in the Growing Up Today Study 2 between 2004 and 2013, and their mothers participating in the Nurses Health Study 2. Outcome definitions were based on self-reported physician diagnosed depression or anxiety, regular antidepressant use, and depressive symptoms (assessed via the Center for Epidemiologic Studies Depression Scale). Generalized estimating equations regression models were used to estimate multivariable adjusted ORs and 95%Cis. We observed no association between maternal nightshift work before pregnancy and risk of any of the considered mental health disorders in their children. Similarly, longer duration of nightshift work was not associated with the risk of any of the considered outcomes (all PTrend>0.09). However, compared to offspring of women without a history of rotating nightshift work, risk of depression was significantly elevated for offspring of women with any rotating nightshift work before pregnancy if they were definite morning chronotypes (OR=l.92; 95%CI=l.16-3.18), whereas this was not the case for women with intermediate or evening chronotypes (OR =0.92; 95%CI=0.67-l.26; Pinteraction=0.004). Risks of mental health outcomes for children of women with or without nightshift work during pregnancy were not significantly different. Overall, while nightshift work before or during pregnancy was not associated with offspring mental health in our study, our results indicate that maternal chronotype might play a role in the relationship between nightshift work before pregnancy and offspring depression outcomes. [Description provided by NIOSH]
• Subjects:
  Adolescent Cohort Studies Health Personnel Mental Health Nervous System Occupational Health Pregnancy Safety
• Keywords:
  Nurses; Nursing; Shift workers; Health effects; Work schedules; Cohort studies; Pregnancy; Mental health; Adolescents
• Publisher:
  Society for Epidemiologic Research
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Abstract or Summary
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• NIOSHTIC Number:
  nn:20065380
• Citation:
  51st Annual Society for Epidemiologic Research (SER) Meeting, June 19-22, 2018, Baltimore, Maryland. Clearfield, UT: Society for Epidemiologic Research, 2018 Jun; :462
• Federal Fiscal Year:
  2018
• Performing Organization:
  Brigham and Women's Hospital, Inc., Boston, Massachusetts
• Peer Reviewed:
  False
• Start Date:
  20100801
• Source Full Name:
  51st Annual Society for Epidemiologic Research (SER) Meeting, June 19-22, 2018, Baltimore, Maryland
• End Date:
  20190831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f23710d977d63665a3a354e8b43528c671d4786de8ccf9bed1a0c5d9ae914ed6f339ed4d708e1e1528e5bdc7d30b3e574e3de882ad546fd05f77aa11f33b29e6
• Download URL:
  https://stacks.cdc.gov/view/cdc/248925/cdc_248925_DS1.pdf
• File Type:
  [PDF - 262.30 KB ]