Lung Cancer Incidence Among World Trade Center Rescue and Recovery Workers

Details

• Personal Author:
  de la Hoz RE ; Kong CY ; Markowitz SB ; Sigel K ; Stone K ; Todd AC ; Wisnivesky JP
• Description:
  Background: Many World Trade Center disaster (WTC) rescue and recovery workers (WTC RRWV) were exposed to toxic inhalable particles. The impact of WTC exposures on lung cancer risk is unclear. Methods: Data from the WTC Health Program General Responders Cohort (WTCGRC) were linked to health information from a large New York City health system to identify incident lung cancer cases. Incidence rates for lung cancer were then calculated. As a comparison group, we created a microsimulation model that generated expected lung cancer incidence rates for a WTC- and occupationally-unexposed cohort with similar characteristics. We also fitted a Poisson regression model to determine specific lung cancer risk factors for WTC RRWV. Results: The incidence of lung cancer for WTC RRWV was 39.5 (95% confidence interval [CI]: 30.7-49.9) per 100,000 person-years. When compared to the simulated unexposed cohort, no significant elevation in incidence was found among WTC RRWV (incidence rate ratio [IRR] 1.34; 95% CI: 0.92-1.96). Predictors of lung cancer incidence included age, smoking intensity, and years since quitting for former smokers. In adjusted models evaluating airway obstruction and individual pre-WTC occupational exposures, only mineral dust work was associated with lung cancer risk (IRR: 2.03; 95% CI: 1.07-3.86). Discussion: In a sample from a large, prospective cohort of WTC RRWV we found a lung cancer incidence rate that was similar to that expected of a WTC- and occupationally-unexposed cohort with similar individual risk profiles. Guideline-concordant lung cancer surveillance and periodic evaluations of population-level lung cancer risk should continue in this group. [Description provided by NIOSH]
• Subjects:
  Aging Emergency Responders Environmental Exposure Hazardous Substances Lung Lung Diseases Neoplasms Occupational Health Particulate Matter Respiratory System Respiratory Tract Diseases Risk Assessment Risk Factors Safety September 11 Terrorist Attacks Smokers Workplace

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• Keywords:
  Author Keywords: Lung Cancer; Lung Diseases; Occupational Diseases; Occupational Lung Disease; Respiratory Diseases Lung Cancer; Rescue Workers; WTC; World Trade Center; Disaster Sites; Disaster Recovery; Workers; Work Environment; Exposure Levels; Risk Factors; Toxins; Particulates; Simulation Methods; Models; Statistical Analysis; Age Groups; Smoking; Airway Obstruction; Sampling;
• DOI:
  https://doi.org/10.1002/cam4.4672
• ISSN:
  2045-7634
• Document Type:
  Text
• Funding:
  Cooperative Agreement ; Contract
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  11
• Issue:
  16
• NIOSHTIC Number:
  nn:20064864
• Citation:
  Cancer Med 2022 Aug; 11(16):3136-3144
• Contact Point Address:
  Keith Sigel, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1087, New York, NY 10029
• Email:
  keith.sigel@mssm.edu
• Federal Fiscal Year:
  2022
• Performing Organization:
  Icahn School of Medicine at Mount Sinai, New York
• Peer Reviewed:
  True
• Start Date:
  20180701
• Source Full Name:
  Cancer Medicine
• End Date:
  20210630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e44f3f274c13547264ada5f42a226181f0783eaa3ee133175d18bb3702114212076d4fb30789591ba7f46d88942253353f7e1cbf26e02df4d76b8c20cc479a49
• Download URL:
  https://stacks.cdc.gov/view/cdc/248911/cdc_248911_DS1.pdf
• File Type:
  [PDF - 605.19 KB ]