Characterizing the joint effects of pesticide exposure and criteria ambient air pollutants on pediatric asthma morbidity in an agricultural community.

Details

• Personal Author:
  Benka-Coker WO ; Karr C ; Loftus C ; Magzamen S
• Description:
  Background: Environmental contributions to pediatric asthma morbidity have been studied extensively in urban settings; exposures characteristic of agricultural and rural communities have received less attention despite a comparable burden of morbidity. Methods: We obtained repeated urine samples (n = 139) from 16 school-age children with asthma in the Yakima Valley of Washington State between July and October 2012. Biomarkers of organophosphate (OP) pesticide exposure (dialkyl phosphates [DAPs]) and asthma exacerbation (leukotriene E4 [LTE4]) were analyzed in samples. Corresponding 24-hour average particulate matter <2.5 µg (PM2.5) and maximum 8-hour ozone concentration data for the study period were available from local monitoring stations. We evaluated the independent and multi-pollutant associations between LTE4 and exposure to ambient air pollutants and DAPs using generalized estimating equations. For multi-domain and multi-pollutant models, we created categorized pollution combination levels and estimated the relative health impact of exposure to pollutant mixtures. Results: In single-pollutant models, an interquartile range increase in exposures to DAPs was associated with increase in LTE4 levels (beta: 4.1 [0.6-7.6] pg/mg). PM2.5 and ozone were also associated with increase in LTE4, though confidence intervals contained the null value. Increase in LTE4 levels was consistently associated with increase in median-dichotomized multi-pollutant combination exposures; the highest effect estimates were observed with joint highest (vs. the lowest) category of the three-pollutant exposure (PM2.5, ozone, and OP; beta: 53.5, 95% confidence interval = 24.2, 82.8 pg/mg). Conclusion: Concurrent short-term exposure to criteria air pollutants and OPs in an agricultural community was associated with an increase in a marker of asthma morbidity. [Description provided by NIOSH]
• Subjects:
  Agriculture Air Pollutants, Occupational Air Pollution Asthma Asthma, Occupational Biomarkers Community Health Services Environmental Exposure Insecticides Occupational Health Safety

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• Keywords:
  Agricultural Industry; Agriculture; Pesticides And Agricultural Chemicals; Asthma; Children; Environmental Exposure; Community Health; Air Pollution; Air Pollutants; Author Keywords: Pollutant Mixtures; Agricultural Settings; Pediatric Asthma; Biomarkers
• ISSN:
  2474-7882
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Colorado ; OSHA Region 10 ; OSHA Region 8 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  3
• Issue:
  3
• NIOSHTIC Number:
  nn:20065425
• Citation:
  Environ Epidemiol 2019 May; 3(3):e046
• Contact Point Address:
  Wande Benka-Coker, Department of Environmental and Radiological Health Sciences, Colorado State University, 1681 Campus Delivery, Fort Collins, CO 80523
• Email:
  abenkac@gmail.com
• CAS Registry Number:
  Ozone (CAS RN 10028-15-6)
• Federal Fiscal Year:
  2019
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Performing Organization:
  University of Washington
• Peer Reviewed:
  True
• Start Date:
  20010930
• Source Full Name:
  Environmental Epidemiology
• End Date:
  20270929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:bf5bf4c8209f6bed33db95d051e1b98011b830b9f19ee410c4f5b24088537904913272cb562eb02f4ed002772bdebcb10a1101ecc427bea5e44e0884450c252b
• Download URL:
  https://stacks.cdc.gov/view/cdc/248782/cdc_248782_DS1.pdf
• File Type:
  [PDF - 417.99 KB ]