U.S. flag An official website of the United States government.
Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

i

Bone shock absorption in pediatric patients with osteogenesis imperfecta - a pilot study to assess the potential of this technique to detect differences in bone fragility.



Details

  • Personal Author:
  • Description:
    Inadequate bone mass acquisition during childhood is associated with an increased lifetime risk for fractures. Currently, dual energy x-ray absorptiometry (DXA) is used clinically to measure areal bone mineral density (aBMD) but is not sensitive enough to quantify risk of fragility fractures in children. Osteogenesis imperfecta (OI) is most commonly due to mutations in collagen (COL1A1 or COL1A2) that impairs triple helix formation, resulting in decreased bone mineralization. OI type 1 is the mildest form, generally present during childhood with recurrent fragility fractures. Treatment with bisphosphonate therapy has been shown to increase aBMD and reduce fractures, but is generally reserved for those suffering multiple fractures per year. Clinical decision making on bisphosphonate use is often based on aBMD Z score. Despite improvements in aBMD, fracture rates remain elevated indicating that there are other factors to consider in assessing skeletal integrity of children with primary forms of osteoporosis. Bone Shock Absorption (BSA) is a technique that measures damping, the ability of bone to absorb external forces, dynamically. Higher damping indicates an increased resistance to fracture. BSA has been validated in postmenopausal women diagnosed with osteoporosis (by DXA), differentiating those with and without fractures. BSA has not previously been tested in young children but offers an alternative, noninvasive method to assess the skeletal integrity of children with bone disease. Here we report the use of the BSA technique in prepubertal children to gather preliminary data on its ability to discriminate the degree of bone fragility in those with OI compared to healthy children of similar age, sex, and race. [Description provided by NIOSH]
  • Subjects:
  • Keywords:
  • ISSN:
    1094-6950
  • Document Type:
    Text
  • Funding:
    Grant
  • Genre:
    Journal Article
  • Place as Subject:
  • CIO:
    National Institute for Occupational Safety and Health (NIOSH)
  • Topic:
    Workplace Safety & Health
  • Location:
    North America
  • Volume:
    23
  • Issue:
    4
  • NIOSHTIC Number:
    nn:20065131
  • Citation:
    J Clin Densitom 2020 Oct-Dec; 23(4):685-689
  • Contact Point Address:
    Halley Wasserman, MD, MSc, CCD, Department of Endocrinology, Cincinnati Children's Hospital, 3333 Burnet Ave, MLC 7012, Cincinnati, OH 45226
  • Email:
    halley.wasserman@cchmc.org
  • Federal Fiscal Year:
    2021
  • Performing Organization:
    University of Cincinnati
  • Peer Reviewed:
    True
  • Start Date:
    20050701
  • Source Full Name:
    Journal of Clinical Densitometry
  • End Date:
    20260630
  • Collection(s):
  • Main Document Checksum:
    urn:sha-512:2b8ccb47abcb5f2fd2bf7071d937b11f19261f7bec7cf1b8b77d76c29122291a1fdbc0379bad92bd0b0e884c03cfd7be728d89c2334698eea0ee22174c6f0d29
  • Download URL:
  • File Type:
    Filetype[PDF - 1.01 MB ]
PREVIOUS
ON THIS PAGE
Details
CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners.

As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.
BACK TO TOP