Kidney injury risk during prolonged exposure to current and projected wet bulb temperatures occurring during extreme heat events in healthy young men.

Details

• Personal Author:
  Baker TB ; Basile DP ; Chapman CL ; Hess HW ; Hostler D ; Johnson BD ; Monroe JC ; Pryor RR ; Schlader ZJ ; Stooks JJ
• Description:
  Wet bulb temperatures (Twet) during extreme heat events are commonly 31 degrees C. Recent predictions indicate that Twet will approach or exceed 34 degrees C. Epidemiological data indicate that exposure to extreme heat events increases kidney injury risk. We tested the hypothesis that kidney injury risk is elevated to a greater extent during prolonged exposure to Twet=34 degrees C compared to Twet=31 degrees C. Fifteen healthy men rested for eight hours in Twet=31 (0) degrees C and Twet=34 (0) degrees C. Insulin-like growth factor-binding protein 7 [IGFBP7], tissue inhibitor of metalloproteinase 2 [TIMP-2], and thioredoxin 1 (TRX-1) were measured from urine samples. The primary outcome was the product of IGFBP7 and TIMP-2 [IGFBP7·TIMP-2], which provided an index of kidney injury risk. Plasma interleukin-17a (IL-17a) was also measured. Data are presented at pre and after eight hours of exposure, and as mean (SD) change from preexposure. The increase in [IGFBP7·TIMP-2] was markedly greater at eight hours in the 34 degrees C (+26.9 (27.1) [ng/mL]2/1000) compared to the 31 degrees C (+6.2 (6.5) [ng/mL]2/1000) trial (p<0.01). Urine TRX-1, a marker of renal oxidative stress, was higher at eight hours in the 34 degrees C (+77.6 (47.5) ng/min) compared to the 31 degree C (+16.2 (25.1) ng/min) trial (p<0.01). Plasma IL-17a, an inflammatory marker, was elevated at eight hours in the 34 degrees C (+199.3 (90.0) fg/dL; p<0.01) compared to the 31 degrees C (+9.0 (95.7) fg/dL) trial. Kidney injury risk is exacerbated during prolonged resting exposures to Twet experienced during future extreme heat events (34 degree C) compared to that experienced currently (31 degree C), likely due to oxidative stress and inflammatory processes. [Description provided by NIOSH]
• Subjects:
  Epidemiology Heat Stress Disorders Hot Temperature Men Occupational Health Risk Assessment Risk Factors Safety Urine
• Keywords:
  Author Keywords: Acute Kidney Injury; Heat Stress; Heat Waves; Kidney Function Humans; Men; Kidneys; Kidney Disorders; Heat; Heat Exposure; Heat Stress; Epidemiology; Kidney Damage; Risk Factors; Injuries; Proteins; Urinalysis; Urine; Sampling; Oxidative Stress;
• ISSN:
  8750-7587
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Indiana ; New York ; Oregon ; OSHA Region 10 ; OSHA Region 2 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  27-40
• Volume:
  133
• Issue:
  1
• NIOSHTIC Number:
  nn:20065301
• Citation:
  J Appl Physiol 2022 Jul; 133(1):27-40
• Contact Point Address:
  Zachary J. Schlader, Department of Kinesiology, School of Public Health, Indiana University, Bloomington, IN, United States
• Email:
  zschlade@iu.edu
• Federal Fiscal Year:
  2022
• NORA Priority Area:
  Agriculture, Forestry and Fishing ; Construction
• Performing Organization:
  Indiana University, Bloomington
• Peer Reviewed:
  True
• Start Date:
  20190901
• Source Full Name:
  Journal of Applied Physiology
• End Date:
  20240831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a2c167f9369ce582b45e7f31f308c627288758851c65bf92944f24589e672a7019bffcaf1f3c1a6e6d218c3ba69db80673fadf582497db3c86b41fa66d1a46b2
• Download URL:
  https://stacks.cdc.gov/view/cdc/248692/cdc_248692_DS1.pdf
• File Type:
  [PDF - 1.14 MB ]