Global DNA methylation profiles in peripheral blood of WTC-exposed community members with breast cancer.

Details

• Personal Author:
  Arslan AA ; Chen Y ; Durmus N ; Heguy A ; Reibman J ; Shao Y ; Snuderl M ; Tuminello S ; Yang L ; Zeleniuch-Jacquotte A ; Zhang Y
• Description:
  Breast cancer represents the most common cancer diagnosis among World Trade Center (WTC)-exposed community members, residents, and cleanup workers enrolled in the WTC Environmental Health Center (WTC EHC). The primary aims of this study were (1) to compare blood DNA methylation profiles of WTC-exposed community members with breast cancer and WTC-unexposed pre-diagnostic breast cancer blood samples, and (2) to compare the DNA methylation differences among the WTC EHC breast cancer cases and WTC-exposed cancer-free controls. Gene pathway enrichment analyses were further conducted. There were significant differences in DNA methylation between WTC-exposed breast cancer cases and unexposed prediagnostic breast cancer cases. The top differentially methylated genes were Intraflagellar Transport 74 (IFT74), WD repeat-containing protein 90 (WDR90), and Oncomodulin (OCM), which are commonly upregulated in tumors. Probes associated with established tumor suppressor genes (ATM, BRCA1, PALB2, and TP53) were hypermethylated among WTC-exposed breast cancer cases compared to the unexposed group. When comparing WTC EHC breast cancer cases vs. cancer-free controls, there appeared to be global hypomethylation among WTC-exposed breast cancer cases compared to exposed controls. Functional pathway analysis revealed enrichment of several gene pathways in WTC-exposed breast cancer cases including endocytosis, proteoglycans in cancer, regulation of actin cytoskeleton, axon guidance, focal adhesion, calcium signaling, cGMP-PKG signaling, mTOR, Hippo, and oxytocin signaling. The results suggest potential epigenetic links between WTC exposure and breast cancer in local community members enrolled in the WTC EHC program. [Description provided by NIOSH]
• Subjects:
  Cohort Studies Environmental Exposure Genetics Occupational Health Safety September 11 Terrorist Attacks
• Keywords:
  Author Keywords: Environmental Exposure; Epigenome-wide Association Study; Exposure Assessment; Methylation; Pathway Analysis; World Trade Center; 9/11; Breast Cancer WTC; World Trade Center; Environmental Exposure; Breast Cancer; Gene Regulation; Genes; DNA Damage; Signaling Pathways; Cell Signaling; Molecular Epidemiology; Cohort Studies;
• ISSN:
  1660-4601
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; New York ; OSHA Region 1 ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  19
• Issue:
  9
• NIOSHTIC Number:
  nn:20065203
• Citation:
  Int J Environ Res Public Health 2022 May; 19(9):5104
• Contact Point Address:
  Stephanie Tuminello, Department of Population Health, New York University Langone Health, New York, NY 10016, USA
• Email:
  stephanie.tuminello@nyulangone.org
• Federal Fiscal Year:
  2022
• Performing Organization:
  New York University School of Medicine
• Peer Reviewed:
  True
• Start Date:
  20210701
• Source Full Name:
  International Journal of Environmental Research and Public Health
• End Date:
  20230630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:48ca15f4b510b36315ae027dcec61e42df2623bd4a205f6167cc93086bf874aa29095520f99dda60903c5dbfa234a8caef1a21e118e6d9b5435b3de362b18056
• Download URL:
  https://stacks.cdc.gov/view/cdc/248684/cdc_248684_DS1.pdf
• File Type:
  [PDF - 1.16 MB ]