Extraction and chemistry of rubber allergens.

Details

• Personal Author:
  Siegel, Paul D.
• Description:
  Latex rubber protective gloves are a known cause of both Type 1 and Type IV hypersensitivity reactions. The proteins found in natural latex caused an epidemic of IgE-mediated occupational contact urticaria, asthma, and anaphylaxis in the 1980s, while rubber additives such as vulcanization accelerators are a common cause of hand allergic contact dermatitis (ACD). Three main topics are discussed in this chapter: measurement of latex proteins, chemical analyses of rubber additives from gloves, and studies of chemical mechanisms of rubber accelerator haptenation. The standardized immunochemical assays developed to measure extractable total latex proteins, antigenic proteins, and specific latex allergens played a role in reducing protein allergens in latex rubber gloves. Extraction and analysis of rubber chemical additives from both natural and synthetic rubber gloves can be quite complex, and although low accelerator gloves are available, rubber accelerator contact allergy remains a problem. [Description provided by NIOSH]
• Subjects:
  Hypersensitivity Immune System Occupational Health Personal Protective Equipment Safety
• Keywords:
  Latex; Gloves; Hypersensitivity; Contact dermatitis; Allergic reactions; Allergies; Immune reaction
• ISBN:
  9781003126874
• Publisher:
  CRC Press
• Document Type:
  Text
• Genre:
  Book
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  45-60
• NIOSHTIC Number:
  nn:20068204
• Citation:
  Protective gloves for occupational use, third edition. Phalen RN, Maibach H, eds. Boca Raton, FL: CRC Press, 2022 Nov; :45-60
• Editor(s):
  Phalen RN; Maibach H
• Federal Fiscal Year:
  2023
• Peer Reviewed:
  False
• Source Full Name:
  Protective gloves for occupational use, third edition
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/248304/cdc_248304_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]