Biomarkers in monitoring for efficacy of immunotherapy and chemoprevention of bladder cancer with dimethylsulfoxide.

Details

• Personal Author:
  Bonner RB ; Hemstreet GP 3rd ; Hurst RE ; Mellott JE ; Rao J ; Rooker GM
• Description:
  This study correlated biomarkers expressed in tumor and epithelial field with clinical response and recurrence. Of 25 bladder cancer patients, 11 received 6 weeks of intravesical Bacille Calmette-Guerin (BCG), and 14 were treated weekly with intravesical dimethylsulfoxide (DMSO) for 4 weeks to further modulate biomarker expression. G-actin, DNA aneuploidy, and p300 tumor antigen were evaluated by quantitative fluorescence image analysis on uroepithelial cells from bladder wash samples prior to and immediately following treatment. Excluding patients who did not respond to BCG (and who had persistently abnormal p300 and DNA markers), recurrence correlated with persistent abnormal G-actin findings. Of patients who were G-actin negative following therapy, only 25% recurred during follow-up in contrast to 67% in patients who were positive (p < 0.03 by Fisher's exact test). The odds ratio for recurrence was 6.00 (95% confidence interval: 1.3-28.6). Cytosolic G-actin levels can be an important intermediate end point marker for chemoprevention. [Description provided by NIOSH]
• Subjects:
  Carcinogens Cytotoxins DNA Epidemiology Neoplasms Occupational Health Risk Assessment Safety
• Keywords:
  Cancer; DNA-damage; Cytotoxic-effects; Carcinogens; Carcinogenesis; Risk-analysis; Epidemiology; Biological-monitoring
• ISSN:
  0361-090x
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Oklahoma ; OSHA Region 6
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  163-171
• Volume:
  23
• Issue:
  2
• NIOSHTIC Number:
  nn:20031361
• Citation:
  Cancer Detect Prev 1999 Mar; 23(2):163-171
• Contact Point Address:
  Department of Urology, University of Oklahoma Health Sciences Center, Oklahoma City
• Federal Fiscal Year:
  1999
• Performing Organization:
  University of Oklahoma Hlth Sciences Ctr, Oklahoma City, Oklahoma
• Peer Reviewed:
  True
• Start Date:
  19890930
• Source Full Name:
  Cancer Detection and Prevention
• End Date:
  19990430
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/248007/cdc_248007_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]