Lung injury and fibrogenic response to dusts from citrus and grape harvests.

Details

• Personal Author:
  Allamneni KP ; Last JA ; Lawson R ; McCurdy SA ; Rajini P ; Southard RJ ; Witschi H
• Description:
  Dusts from leaf surfaces in vineyards and citrus groves were evaluated during harvest season for fibrogenic potential in rats. Using a canopy, dust from leaves was collected during harvest from three orchards and three vineyards. Male Sprague-Dawley-rats received intratracheal instillations of the dust samples suspended in saline, and lung lavage fluid was collected for analysis 3 days later. None of the dusts produced a significant increase in protein content of lung fluid. Both dusts produced an increase in total number of cells recovered from lung lavage fluids, which was significant for one of the vineyard dusts. A significantly higher percentage of polymorphonuclear leukocytes occurred for citrus orchard dust exposed rats. Biochemical analysis of lung tissue showed that vineyard dust, but not orchard dust, had fibrogenic potential. The authors conclude that their findings may be important for human epidemiologic data, and future studies should confirm the effect of vineyard dust to cause fibrotic lung changes with chronic exposure. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Dust Laboratories Occupational Health Particulate Matter Respiratory Tract Diseases Safety
• Keywords:
  NIOSH-Publication; NIOSH-Cooperative-Agreement; Laboratory-animals; Dust-exposure; Dust-inhalation; Dust-particles; Airborne-dusts; Pulmonary-system-disorders; Agricultural-products;
• ISSN:
  0895-8378
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  363-376
• Volume:
  7
• Issue:
  3
• NIOSHTIC Number:
  nn:00235068
• Citation:
  Inhal Toxicol 1995 Apr; 7(3):363-376
• Federal Fiscal Year:
  1995
• Performing Organization:
  University of California - Davis
• Peer Reviewed:
  True
• Start Date:
  19900930
• Source Full Name:
  Inhalation Toxicology
• End Date:
  20020929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/247881/cdc_247881_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]