Overview and summary: Workshop on the Chernoff/Kavlock preliminary developmental toxicity test.

Details

• Personal Author:
  Becker RA ; Chernoff N ; Hardin, Bryan D. ; Kavlock RJ ; Seidenberg JM
• Description:
  The views presented at a workshop on the Chernoff/Kavlock assay (CKA) were summarized, and information from three major testing programs on 165 chemicals was consolidated. Of 58 chemicals classified as developmentally toxic and 34 classified as nontoxic, 49 were identified by CKA as developmentally toxic and 28 as nontoxic. Equivocal results were obtained for four toxic and for two nontoxic chemicals. Five developmentally toxic and four developmentally nontoxic chemicals were classified incorrectly. The participants agreed on several aspects. Performing tests at two dose levels would increase predictive value. Reduced terminal body weight and diminished body weight gain over selected intervals were proposed as alternative indices of maternal toxicity. Predictive values of the test would be increased if the same species were used in followup studies. Data supported the use of rats in the assay. Each chemical must be evaluated individually. Any adverse effect was considered as evidence of potential developmental toxicity. The practical need was recognized to establish priorities for further testing within a set of chemicals that produced some effect in CKA. Compared to other programs, CKA did not require a high degree of technical expertise and provided data on neonatal viability. CKA provided information on maternal (mortality, body weight, and body weight changes) and developmental toxicity (viable litters, number of live pups per viable litter, percent neonatal survival for several postnatal days, average weight, and average weight gain). The participants assessed CKA as a useful testing alternative that was validated for general application. [Description provided by NIOSH]
• Subjects:
  Environmental Exposure Environmental Pollution Hazardous Substances Inorganic Chemicals Laboratories Occupational Health Safety Teratogenesis Urogenital Diseases Urogenital System
• Keywords:
  Author Keywords: In Vivo Screen; Teratogen; Hazard Detection; Rodent; Pregnancy Outcome; Neonatal Viability NIOSH-Author; In-vivo-studies; Laboratory-animals; Toxic-materials; Acute-toxicity; Embryotoxicity; Teratogens; Environmental-hazards; Screening-methods; Inorganic-chemicals; Organic-chemicals; Reproductive-hazards;
• ISSN:
  0270-3211
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  California ; North Carolina ; Ohio ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSDTT - Division of Standards Development and Technology Transfer
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  119-127
• Volume:
  7
• Issue:
  1
• NIOSHTIC Number:
  nn:00169372
• Citation:
  Teratog, Carcinog, Mutagen 1987 Jan; 7(1):119-127
• Contact Point Address:
  Bryan D. Hardin, Division of Standards Development and Technology Transfer, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, Ohio 45226
• Federal Fiscal Year:
  1987
• Peer Reviewed:
  True
• Source Full Name:
  Teratogenesis, Carcinogenesis, and Mutagenesis
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/247599/cdc_247599_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]