Organoisocyanates.

Details

• Description:
  The molecular structure, Chemical Abstracts Service number, Registry of Toxic Effects of Chemical Substances number, production figures, uses, and producer and user data are provided for organoisocyanates, toluene-2,4-diisocyanate (584849) (TDI), toluene-2,5-diisocyanate (91087), toluene-2,4-diisocyanate and 2,6-diisocyanate mixture, methyl-isocyanate (624839), phenyl-isocyanate (103719), m- chlorophenyl-isocyanate (2909388), and p-chlorophenyl-isocyanate (104121). The isocyanates in vapor form have a strongly irritating effect on all mucous membranes. After 8 days to two months of exposure to TDI, workers complain of eye, throat, and bronchial irritation, followed by asthmatic attacks. Case reports indicate that bronchospasm is the chief effect of TDI. A threshold limit value of 0.02ppm is recommended for TDI and methyl-isocyanate. (Contract No. 210-77-0120) [Description provided by NIOSH]
• Subjects:
  Asthma Asthma, Occupational Eye Foreign Bodies Hazardous Substances Herbicides Irritants Isocyanates Occupational Health Polyurethanes Respiratory Tract Diseases Safety

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• Keywords:
  NIOSH-Contract; Contract-210-77-0120; Herbicides; Toxic-substances; Cyanates; Irritants; Respiratory-system-disorders; Bronchial-asthma; Polyurethanes; Eye-irritants; Exposure-limits
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Report
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  265-275
• NIOSHTIC Number:
  nn:00075432
• Citation:
  NIOSH 1977 Oct; :265-275
• CAS Registry Number:
  3-Chlorophenyl isocyanate (CAS RN 2909-38-8) ; 4-Chlorophenyl isocyanate (CAS RN 104-12-1) ; Methyl isocyanate (CAS RN 624-83-9) ; Phenyl isocyanate (CAS RN 103-71-9) ; Toluene 2,4-diisocyanate (CAS RN 584-84-9) ; Toluene 2,6-diisocyanate (CAS RN 91-08-7)
• Federal Fiscal Year:
  1978
• NORA Priority Area:
  Disease and Injury: Asthma and Chronic Obstructive Pulmonary Disease
• Peer Reviewed:
  False
• Source Full Name:
  Information Profiles on Potential Occupational Hazards, NIOSH Contract No. 210-77-0120, October 1977
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/247450/cdc_247450_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]