Effects of zinc oxide welding fume inhalation.

Details

• Personal Author:
  Blanc PD
• Description:
  The purpose of this research was to determine whether inhalation of zinc-oxide (1314132) fourths causes a dose dependent inflammatory response in the lungs, to determine if pulmonary function changes correlate with such inflammatory changes, and to determine if cytokines are important in the development of metal fume fever. The study group included 23 volunteers who carried out 26 experimental welding procedures. The zinc-oxide welding fume inhalation was shown to be associated with a dose dependent, marked inflammatory cellular response in the lung whether or not clinical symptoms of metal fume fever were reported. Pulmonary function changes were negligible. The time course of increased cytokines, their correlations with one another and with polymorphonuclear leukocytes in the bronchoalveolar lavage fluid and the consistency of the findings with the known kinetics and actions of these cytokines supports the hypothesis that a network of cytokines is involved in the pathogenesis of metal fume fever. The authors suggest that understanding the mechanism of zinc-oxide effects may assist in understanding a group of illnesses representing an important clinical problem in occupational medicine. Zinc-oxide inhalation is seen as a useful model to study general mechanisms of cellular responses to inhaled toxicant in the human lung along with their pulmonary function and systemic manifestations. [Description provided by NIOSH]
• Subjects:
  Lung Occupational Health Respiratory System Respiratory Tract Diseases Safety Zinc Compounds
• Keywords:
  NIOSH-Grant; Occupational-respiratory-disease; Zinc-compounds; Lung-function; Pulmonary-system-disorders; Pulmonary-function; Inhalation-studies
• Series:
  Grant Final Reports
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Final Grant Report
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-5
• NIOSHTIC Number:
  nn:00232651
• Citation:
  Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, K01-OH-000079, 1993 Nov; :1-5
• Contact Point Address:
  Cardiovascular Research Inst University of California PO Box 0924 San Francisco, CA 94143-0924
• CAS Registry Number:
  Zinc oxide (ZnO) (CAS RN 1314-13-2)
• Federal Fiscal Year:
  1994
• NORA Priority Area:
  Pulmonary System Disorders
• Performing Organization:
  University of California San Francisco
• Peer Reviewed:
  False
• Start Date:
  19900401
• Source Full Name:
  National Institute for Occupational Safety and Health
• End Date:
  19930927
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/246322/cdc_246322_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]