Cumulative trauma disorder: skeletal muscle dysfunction.

Details

• Personal Author:
  Stauber WT
• Description:
  Experiments were designed to develop a reproducible technique for producing chronic strain injury to rat skeletal muscles as a model for cumulative trauma disorder (CTD), and to measure the functional outcome of repeated microtrauma in order to develop strategies and programs for its prevention. A dynamometer was designed and built to control the velocity and range of movement of the rat foot during a strain overload and test the functional outcome in terms of muscle strength, endurance, and stiffness in-vivo. Changes in the extracellular matrix and sarcolemma of skeletal muscles which could result in muscle pathology or adaptation were measured. Cumulative microtrauma was administered three times a week for 4 weeks to one leg of female rats. Muscles became myopathic after 1 month of exposure to repeated strains. The appearance of muscle pathology was related to the strain rate. Repeated high velocity strains were accompanied by myofiber heterogeneity and apparent fibrosis while low velocity strains produced muscle hypertrophy and positive adaptations. These two responses were noted in muscles commonly recruited for low level endurance activity. The authors conclude that appropriate rest periods are important for recovery from metabolic fatigue and repair of tissue damage. [Description provided by NIOSH]
• Content Notes:
  in NTRL, no pdf
• Subjects:
  Cumulative Trauma Disorders Laboratories Musculoskeletal Diseases Musculoskeletal System Occupational Health Safety
• Keywords:
  NIOSH Grant; Musculoskeletal system disorders; Muscle function; Repetitive work; Laboratory animals; Cumulative trauma disorders
• Series:
  Grant Final Reports
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Final Grant Report
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-10
• NIOSHTIC Number:
  nn:00228277
• NTIS Accession Number:
  PB95269957
• Citation:
  Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, R01-OH-002918, 1995 Mar; :1-10
• Contact Point Address:
  Physiology West Virginia University 3051 Health Sciences North Morgantown, WV 26506
• Federal Fiscal Year:
  1995
• Performing Organization:
  West Virginia University, Morgantown, West Virginia
• Peer Reviewed:
  False
• Start Date:
  19920101
• Source Full Name:
  National Institute for Occupational Safety and Health
• End Date:
  20050531
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/246305/cdc_246305_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]