Halogenated hydrocarbon toxicity in proximal tubules.

Details

• Personal Author:
  Hjelle JT ; Miller MA ; Hjelle JT ; Miller MA
• Description:
  A study was conducted to examine the validity of the isolated rabbit tubule model as a tool in the study of nephrotoxicants and to determine the validity of the rabbit tubule model as a predictor of nephrotoxicity in humans. Kidney proximal tubules were isolated from control and phenobarbital induced rabbits by nonenzymatic sieving techniques and then studied in-vitro. Proximal tubules obtained in bulk by nonenzymatic procedures were resistant to cell damage by levels of chloroform (67663) and carbon-tetrachloride (56235) likely to be encountered in the work place. Drug treatment of the rabbits followed by tubule isolation and exposure to these solvents in-vitro did not enhance cell damage. Tubule cells propagated in-vitro were more susceptible to cell damage caused by these organic solvents. [Description provided by NIOSH]
• Content Notes:
  in NTRL, no pdf
• Subjects:
  Hydrocarbons Laboratories Occupational Health Safety Urogenital Diseases Urogenital System
• Keywords:
  NIOSH-Grant; Grants-other; Laboratory-animals; Renal-toxicity; Chlorinated-hydrocarbons; Kidney-damage; In-vitro-studies
• Series:
  Grant Final Reports   ; Grant Final Reports  
• Publisher:
  College of Medicine at Peoria, University of Illinois
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Final Grant Report ; Final Grant Report
• Place as Subject:
  Illinois ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs ; OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Pages in Document:
  1-11
• NIOSHTIC Number:
  nn:00200824
• NTIS Accession Number:
  PB92109271
• Citation:
  College of Medicine at Peoria, University of Illinois, Peoria, Illinois 1991 May; :1-11
• Contact Point Address:
  Basic Sciences University of Illinois One Illini Drive, Box 1659 Peoria, IL 61656
• CAS Registry Number:
  Carbon tetrachloride (CAS RN 56-23-5) ; Chloroform (CAS RN 67-66-3) ; Carbon tetrachloride (CAS RN 56-23-5) ; Chloroform (CAS RN 67-66-3)
• Federal Fiscal Year:
  1991
• NORA Priority Area:
  Other Occupational Concerns ; Grants Other ; Other Occupational Concerns ; Grants Other
• Performing Organization:
  College of Medicine at Peoria, Peoria, Illinois
• Peer Reviewed:
  False
• Start Date:
  19870901
• Source Full Name:
  College of Medicine at Peoria, University of Illinois, Peoria, Illinois
• End Date:
  19900831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/246230/cdc_246230_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]