Macrophage, particulates, and carcinogen metabolism.

Details

• Personal Author:
  Wey H
• Description:
  A study was conducted to determine the relationship of arachidonic- acid metabolism induced by phagocytosis of ferric-oxide (1309371) to altered benzo(a)pyrene (50328) (BaP) metabolism induced by the same particulate. Alveolar macrophages (AM) were obtained by tracheal lavage of 7 to 9 week old male Golden-Syrian-hamsters following anesthetization with phenobarbital. AM labeled with tritiated arachidonic-acid were exposed to ferric-oxide particulate; the total lipids were extracted for determination of radioactivity. The major finding of the study was the absence of arachidonic-acid metabolic capacity in isolated adherent hamster AM. It is not known whether this deficiency is due to an inherent difference in enzymatic capacity or to conditions in the isolation procedure resulting in the destruction of enzymatic capacity. The author concludes that the hamster alveolar macrophage is not an appropriate in-vitro model for this research. [Description provided by NIOSH]
• Content Notes:
  in NTRL, no pdf
• Subjects:
  Energy Metabolism Laboratories Lung Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  NIOSH-Grant; Pulmonary-system-disorders; Metabolic-study; Laboratory-animals; Lung-cells; Respiratory-system-disorders
• Series:
  Grant Final Reports
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Final Grant Report
• Place as Subject:
  Missouri ; Ohio ; OSHA Region 5 ; OSHA Region 7
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-16
• NIOSHTIC Number:
  nn:00197332
• NTIS Accession Number:
  PB91173245
• Citation:
  Department of Environmental Health, College of Medicine, University of Cincinnati, Cincinnati, Ohio 1988 Sep; :1-16
• CAS Registry Number:
  Benzo[a]pyrene (CAS RN 50-32-8) ; Iron oxide (Fe2O3) (CAS RN 1309-37-1)
• Federal Fiscal Year:
  1988
• NORA Priority Area:
  Disease and Injury: Asthma and Chronic Obstructive Pulmonary Disease
• Performing Organization:
  , ,
• Peer Reviewed:
  False
• Start Date:
  19611001
• Source Full Name:
  Department of Environmental Health, College of Medicine, University of Cincinnati, Cincinnati, Ohio
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/246204/cdc_246204_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]