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i

Physicochemical aspects of percutaneous penetration and its enhancement.



Details

  • Personal Author:
  • Description:
    The relationship between permeation and penetrant physicochemical properties was examined in a brief review of simple Fickian transport as it pertains to the skin. The goal was to establish a conceptual framework for the prospective assessment and optimization of transdermal transport. Both the physicochemical significance and the major deductions from these two approaches were shown to be in general agreement, particularly the prediction of the effect of penetrant oil/water partition coefficient on transdermal flux, which was consistent with the two methods. Similar dependencies on penetrant physical chemistry were demonstrated by both diffusional and kinetic assessments of skin penetration enhancement. Requirements for successful promotion of a lipophilic drug transdermal flux were quite different from those needed for a hydrophilic penetrant. Evidence for different absorption paths across the stratum corneum was also considered and the impact of penetrant size on transport was addressed. According to the authors, currently held ideas concerning the existence of a putative polar route through the stratum corneum and the dependence of flux on molecular weight should be given further study in light of the findings of this project. [Description provided by NIOSH]
  • Content Notes:
    in NTRL, no pdf
  • Subjects:
  • Keywords:
  • Series:
    Grant Final Reports
  • Document Type:
    Text
  • Funding:
    Grant
  • Genre:
    Final Grant Report
  • Place as Subject:
  • CIO:
    National Institute for Occupational Safety and Health (NIOSH)
  • Division:
    OEP - Office of Extramural Programs
  • Topic:
    Workplace Safety & Health
  • Location:
    North America
  • Pages in Document:
    1-31
  • NIOSHTIC Number:
    nn:00182777
  • NTIS Accession Number:
    PB89129993
  • Citation:
    Departments of Pharmacy and Pharmaceutical Chemistry, Schools of Pharmacy and Medicine, University of California, San Francisco, California, 1987 Dec; :1-31
  • Contact Point Address:
    Pharmacy University of California 926 Medical Sciences Building San Francisco, Calif 94143
  • Federal Fiscal Year:
    1988
  • NORA Priority Area:
    Disease and Injury: Allergic and Irritant Dermatitis
  • Performing Organization:
    University of California San Francisco, San Francisco, California
  • Peer Reviewed:
    False
  • Start Date:
    19840928
  • Source Full Name:
    Departments of Pharmacy and Pharmaceutical Chemistry, Schools of Pharmacy and Medicine, University of California, San Francisco, California
  • End Date:
    19871231
  • Collection(s):
  • Main Document Checksum:
    urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
  • Download URL:
  • File Type:
    Filetype[PDF - 168.02 KB ]
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