Cotton bract and human airway hyperresponsiveness.

Details

• Personal Author:
  Schachter EN ; Witek TJ Jr.
• Description:
  Nonspecific airway response to methacholine (MC) following inhalation of cotton bract extract (CBE) was investigated in 13 volunteers. Five of these 13 demonstrated a ventilatory response to CBE with a 20 percent or larger decrement in the maximal expiratory flow. No such changes were noted on exposure to a normal saline aerosol sham exposure. The peak decrease was 76.5 percent of baseline occurring about 60 to 90 minutes post provocation while the peak decrement following normal saline occurred immediately on inhalation. Mild and transient changes in airway responsiveness to MC were noted. While these findings do not appear to have enormous clinical significance in the case of healthy volunteers, the fact that there was an acute and mild airway hyperresponsiveness to CBE suggested that under conditions of repeated exposure to cotton dust, progressive increases in airway hyperresponsiveness leading to chronic airflow obstruction is possible. In the case of byssinosis, a period of time apparently exists where the acute reversible changes in lung function transform to a chronic and disabling airflow obstruction. [Description provided by NIOSH]
• Content Notes:
  in NTRL, no pdf
• Subjects:
  Dust Occupational Health Respiratory Function Tests Respiratory System Respiratory Tract Diseases Safety Textile Industry
• Keywords:
  NIOSH-Grant; Pulmonary-system-disorders; Inhalation-studies; Cotton-dust; Textile-workers; Textile-mills; Pulmonary-function-tests
• Series:
  Grant Final Reports
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Final Grant Report
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-44
• NIOSHTIC Number:
  nn:00182752
• NTIS Accession Number:
  PB89129928
• Citation:
  Mount Sinai School of Medicine, New York, New York 1987 Nov; :1-44
• Contact Point Address:
  Medicine Mount Sinai Medical Center One Gustave L Levy Place New York, N Y 10029
• Federal Fiscal Year:
  1988
• NORA Priority Area:
  Pulmonary System Disorders
• Performing Organization:
  Mount Sinai School of Medicine, New York, New York
• Peer Reviewed:
  False
• Start Date:
  19860901
• Source Full Name:
  Mount Sinai School of Medicine, New York, New York
• End Date:
  19880331
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/246161/cdc_246161_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]