Mucociliary transport and particle clearance in the human tracheobronchial tree.

Details

• Personal Author:
  Hu JP ; Leikauf G ; Lippmann, Morton ; Spektor D ; Yu CP
• Description:
  A compartmental model to describe mucociliary transport and particle clearance in the tracheobronchial trees was described. A method was proposed for determining the mucociliary transport rate as a function of the airway depth from the retention curve directly. Each airway generation was represented by an escalator. For Weibel's lung model there were 17 airway generations in the tracheobronchial tree. The subject performed a series of respiratory mechanical function tests prior to exposure to a monodisperse ferric-oxide aerosol tagged with technetium-99m. Thoracic retention measurements were started 5 minutes after inhalation and continued throughout the next 8 hours with an additional measurement taken the following day. Mucus velocities in millimeters/minute tended to decrease with the value increase of the generation number, but was nearly a constant between generation 7 and 14. The model was simple and appeared to describe the physical process well. Appropriate adjustments of the subject's airway dimensions were needed to further develop the model so that a single set of values of mucus velocity can be determined for several retention curves using different size particles and breathing patterns. [Description provided by NIOSH]
• Content Notes:
  in NTRL, no pdf
• Subjects:
  Air Pollutants, Occupational Asthma Asthma, Occupational Dust Occupational Health Particulate Matter Respiratory Tract Diseases Safety
• Keywords:
  NIOSH-Grant; Airborne-particles; Dust-inhalation; Pulmonary-system-disorders; Mucous-membranes; Bronchial-asthma
• Series:
  Grant Final Reports
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Final Grant Report
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-4
• NIOSHTIC Number:
  nn:00181319
• NTIS Accession Number:
  PB88247846
• Citation:
  Faculty of Engineering and Applied Sciences, State University of New York at Buffalo, Buffalo, New York, 1988 Jun; :1-4
• Contact Point Address:
  Engineering Science S U N Y - at Buffalo Dept of Engineering Science Buffalo, N Y 14214
• Federal Fiscal Year:
  1988
• Performing Organization:
  State University of New York at Buffalo, Buffalo, New York
• Peer Reviewed:
  False
• Start Date:
  19791201
• Source Full Name:
  Faculty of Engineering and Applied Sciences, State University of New York at Buffalo, Buffalo, New York
• End Date:
  19861130
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/246146/cdc_246146_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]