Industrial dust interaction with respiratory mucosa.

Details

• Corporate Authors:
  National Institute for Occupational Safety and Health
• Description:
  The interaction of selected organic and inorganic particulates with the respiratory epithelium was investigated. Organ cultures of trachea and monolayer cultures of epithelial cells derived from hamster trachea were used. The findings indicated that different types of dust generated different biological responses. The effects of various foreign materials adhering to dust particles were also explored with particular attention given to polycyclic hydrocarbons. An analysis of the uptake of polycyclic hydrocarbons on various types of asbestos (1332214) fibers and their release in conjunction with the proliferative effect on the respiratory epithelium was one such research project. The mechanism of interaction of particulates of different types with the membranes of cells was also studied using erythrocytes, cultured epithelial cells and liposomes with silica (7631869), talc (14807966), montmorillonite (1318930), bentonite (1302789), crocidolite (12001284) and chrysotile (12001295). Studies demonstrated the importance of the zeta potential in determining cytotoxicity. The role of naturally occurring substances such as mucins, surfactants, and proteins in altering the interaction of these particulates with the epithelial cells was discovered. The effects of viral infection on the response of the cavine respiratory epithelium to dust was also studied, and the results indicated that the interaction of carbon with respiratory epithelial cells was enhanced by the formation of multinuclear cells, induced by the virus. [Description provided by NIOSH]
• Content Notes:
  in NTRL, no pdf
• Subjects:
  Air Pollutants, Occupational Asbestos Dust Inorganic Chemicals Occupational Health Particulate Matter Respiratory Tract Diseases Safety
• Keywords:
  NIOSH-Grant; Dust-inhalation; Pulmonary-system-disorders; Airborne-particles; Airborne-fibers; Asbestos-fibers; Mineral-dusts; Airborne-dusts
• Series:
  Grant Final Reports
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Final Grant Report
• Place as Subject:
  OSHA Region 1 ; Vermont
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-4
• NIOSHTIC Number:
  nn:00181315
• NTIS Accession Number:
  PB88248042
• Citation:
  Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, R01-OH-000653, 1982 Aug; :1-4
• Contact Point Address:
  Pathology and Oncology Medical Alumni Building University of Vermont Burlington, VT 05401
• CAS Registry Number:
  Asbestos (CAS RN 1332-21-4) ; Bentonite (CAS RN 1302-78-9) ; Chrysotile (CAS RN 12001-29-5) ; Crocidolite asbestos (CAS RN 12001-28-4) ; Montmorillonite ((Al1.33-1.67Mg0.33-0.67)(Ca0-1Na0-1)0.33Si4(OH)2O10.xH2O) (CAS RN 1318-93-0) ; Silica (CAS RN 7631-86-9) ; Talc (Mg3H2(SiO3)4) (CAS RN 14807-96-6)
• Federal Fiscal Year:
  1982
• NORA Priority Area:
  Pulmonary System Disorders
• Performing Organization:
  University of Vermont & St Agric College, Burlington, Vermont
• Peer Reviewed:
  False
• Start Date:
  19770801
• Source Full Name:
  National Institute for Occupational Safety and Health
• End Date:
  19801130
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/246142/cdc_246142_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]