Safe ocular levels for IR occupational exposures.

Details

• Personal Author:
  Wolbarsht ML
• Description:
  The effects of exposure to elevated temperatures or to infrared radiation (IR) on lens proteins were investigated in-vitro in rabbit and calf lenses and in-vivo in rabbits. Calf lens homogenates were incubated at temperatures ranging from 37 to 45 degrees-C. Isoelectric focused gel analysis of the lenses incubated for 30 minutes at 45 degrees showed a definite loss in the lowest points of the alpha crystallin components. Similar changes occurred at lower temperatures, but at slower rates. The loss of alpha crystallin from the isoelectric focusing pattern was due to aggregation to higher molecular weight particles which could not enter the gel. A very high molecular weight fraction contained alpha crystallin material. Rabbit lenses were exposed in-vitro and in-vivo to IR from a Raychem-IR 500 infrared hand tool with a total irradiance of 65 milliwatts/square centimeter. In-vivo exposures were for 1 hour/day for several months. The concentration of beta crystallin proteins was reduced by in-vivo exposures. In in-vitro studies, the beta crystallin was more resistant to degradation than were mixtures of alpha and gamma crystallins. The findings support the theory that changes in some lens proteins can occur by direct absorption of IR by the lens, and that these changes are different from those seen in the early stages of ultraviolet cataract formation. [Description provided by NIOSH]
• Content Notes:
  in NTRL, no pdf
• Subjects:
  Eye Eye Diseases Infrared Rays Laboratories Occupational Health Radiation Safety Sense Organs Sense Organs / Injuries
• Keywords:
  NIOSH-Grant; Laboratory-animals; Eye-damage; Eye-disorders; Radiation-hazards; Radiation-exposure; Infrared-radiation; Nonionizing-radiation
• Series:
  Grant Final Reports
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Final Grant Report
• Place as Subject:
  North Carolina ; OSHA Region 4
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-21
• NIOSHTIC Number:
  nn:00181241
• NTIS Accession Number:
  PB88247812
• Citation:
  Duke University Eye Center, Durham, North Carolina, Final Report 1978 Nov; :1-21
• Contact Point Address:
  Ophthalmology Department of Ophthalmology Duke University Med Ctr Durham, N C 27710
• Federal Fiscal Year:
  1979
• Performing Organization:
  Duke University, Durham, North Carolina
• Peer Reviewed:
  False
• Start Date:
  19740901
• Source Full Name:
  Duke University Eye Center, Durham, North Carolina, Final Report
• End Date:
  19781130
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/246113/cdc_246113_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]