Immune injury in occupational respiratory disease.

Details

• Personal Author:
  Burrell R ; Snyder I
• Description:
  Work on nine different research projects on immune injury in occupational respiratory disease falling under this grant was reviewed. Topics included the pulmonary activities of Thermoactinomyces-vulgaris and Micropolyspora-faeni, comparison of endotoxin/like properties of T-vulgaris and M-faeni with known enterobacterial lipopolysaccharides, evaluation of inflammatory changes induced in the lung by inhalation of M-faeni spores, cotton dust, cotton bract dust, Escherichia-coli, and purified endotoxin aerosols, evaluation of the effects of inflammatory changes on respiratory immunization with soluble or particulate antigens, investigating the role of APC activation by inflammatory agents, the local and systemic cell mediated immunocompetence of lymphoid cells from unimmunized experimental animals, preparing both a soluble and a particulate form of a protein antigen for aerosol immunization, development of appropriate immunization protocols to deliver soluble and particulate antigen in equal amounts to the lower respiratory tract, and a comparison of the effect of local respiratory immunization with a soluble and particulate form of protein antigen on the induction of local and systemic cell mediated immunity. [Description provided by NIOSH]
• Content Notes:
  in NTRL, no pdf
• Subjects:
  Bacteria Dust Immune System Laboratories Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  NIOSH-Grant; Pulmonary-system-disorders; Immunologic-disorders; Inhalation-studies; Bacterial-dusts; Laboratory-animals; Cotton-dust
• Series:
  Grant Final Reports
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Final Grant Report
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-14
• NIOSHTIC Number:
  nn:00181014
• NTIS Accession Number:
  PB88247622
• Citation:
  Department of Microbiology, West Virginia University Medical Center, Morgantown, West Virginia, Terminal Project Report, 1980 Jan; :1-14
• Contact Point Address:
  Microbiology West Virginia University Med C Department of Microbiology Morgantown, W VA 26506
• Federal Fiscal Year:
  1980
• NORA Priority Area:
  Pulmonary System Disorders
• Performing Organization:
  West Virginia University
• Peer Reviewed:
  False
• Start Date:
  19710601
• Source Full Name:
  Department of Microbiology, West Virginia University Medical Center, Morgantown, West Virginia, Terminal Project Report
• End Date:
  19830831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/246097/cdc_246097_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]