Pulmonary disease in workers exposed to papain: clinical, physiological, and immunological studies.

Details

• Personal Author:
  Culver BD ; Fairshter RD ; Keenan WJ ; Novey HS ; Wells ID ; Wilson AF
• Description:
  The pulmonary effects of papain (9001734) exposure were studied among 23 employees who worked at a company that manufactured a soft contact lens cleaning product. Medical histories were obtained, and subjects underwent pulmonary function and immunological testing. Moderate to severe pulmonary symptoms were found in 12 workers. The presence of immunoglobulin-E (IgE) was correlated with decreased lung volumes and expiratory flow rates and total serum. Specific IgE and precipitating antibodies against papain were correlated with symptomatology, pulmonary function test results, duration and intensity of papain exposure, and atopic history. When 5 of the 12 workers with respiratory symptoms were interviewed 4 to 11 months after job reassignment, all were asymptomatic but abnormal lung function and immunological reactions persisted. The authors conclude that papain acts as an inhalant allergen and is a potent sensitizer in humans. Pulmonary reactions involve inflammation of small airways, alveolar, and interstitial lung tissue, producing symptoms resembling bronchitis and interstitial lung disease. Immunoserological and pulmonary function monitoring is recommended for exposed workers along with the use of personal protective and engineering control measures. [Description provided by NIOSH]
• Content Notes:
  in NTRL, no pdf
• Subjects:
  Enzymes Eye Hypersensitivity Immune System Occupational Health Respiratory Tract Diseases Safety Sense Organs Staff Development
• Keywords:
  Author Keywords: Papain; Pulmonary Disease; Asthma; Occupational Lung Disease; Allergic Lung Disease NIOSH-Grant; Training; Enzymes; Work-practices; Optical-aids; Cleaning-compounds; Immunology; Pulmonary-system-disorders; Physiology; Allergic-reactions; Clinical-symptoms;
• Series:
  Grant Final Reports
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Final Grant Report
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OEP - Office of Extramural Programs
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-30
• NIOSHTIC Number:
  nn:00116202
• NTIS Accession Number:
  PB89121230
• Citation:
  Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, T01-OH-07053, 1982 Aug; :1-30
• Contact Point Address:
  Community and Environ Medicine University of California Dept of Cmnty & Environ Med Irvine, Calif 92664
• CAS Registry Number:
  Papain (CAS RN 9001-73-4)
• Federal Fiscal Year:
  1982
• NORA Priority Area:
  Pulmonary System Disorders
• Performing Organization:
  University of California Irvine, Irvine, California
• Peer Reviewed:
  False
• Start Date:
  19760601
• Source Full Name:
  National Institute for Occupational Safety and Health
• End Date:
  19810731
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/246056/cdc_246056_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]