Integrated chemical and biological analysis of asphalt and pitch fumes.

Details

• Personal Author:
  Harris JC ; Menzies, K.T. ; Niemeier RW ; Thayer PS
• Description:
  The carcinogenic potential of condensed volatiles from roofing asphalts and coal tar pitch was evaluated in mice. Two types of asphalt and two types of coal tar pitch were generated in a laboratory. Male non pigmented Swiss-CD-1-mice and pigmented C3H/HeJ-mice were used. Each mouse received 50 microliters of the appropriate test material twice weekly at a dose limited to 50 percent total solids content or 0.01 percent benzo(a)pyrene (50328) (BaP) in the total mixture. The BaP and other polyaromatic hydrocarbons were determined in each fume mixture through gas chromatography/mass spectrometry. Mice were treated and observed until 85 percent of a group had died or 18 months elapsed. Dead mice were necropsied. Some mice were treated with BaP alone. To simulate the effects of sunlight, some of the mice were exposed to ultraviolet light during the treatment period. Aliphatic hydrocarbons were found to be a major component of asphalt fumes. Survival was comparable for all groups of mice through 11 months for CD-1-mice and 10 months for C3H/HeJ-mice. CD-1-mice had a moderately high total tumor incidence with a low incidence of malignancy. Asphalts produced lower total tumors in the CD-1-mouse strain. The proportion of malignancies was comparable for asphalts and pitches. An inhibitory effect of simulated sunlight was seen in a longer latent period to tumor development. Mean time to tumor development was shorter in asphalt exposed animals than in those exposed to BaP, and incidence of malignancy was higher. For pitch fume materials, carcinogenicity reflected the BaP content while for asphalts it did not. The authors conclude that the carcinogenicity of roofing pitch materials is related to the BaP content of those materials. The carcinogenicity of asphalts cannot be explained on the basis of BaP content. Aliphatic hydrocarbons may be partly responsible for the carcinogenicity of asphalt fumes. [Description provided by NIOSH]
• Subjects:
  Animals Carcinogens Chemistry Chemistry, Analytic Coal Construction Industry Construction Materials Occupational Health Radiation Safety Toxicology

  More +
• Keywords:
  Construction-materials; Coal-products; Carcinogens; Animal-studies; Biological-effects; Toxicopathology; Chemical-composition; Analytical-chemistry; Trace-analysis; Tumorigens; Electromagnetic-radiation
• ISBN:
  9780306411915
• Publisher:
  Plenum Press
• Document Type:
  Text
• Genre:
  Proceedings
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DBBS - Division of Biomedical and Behavioral Sciences
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  351-366
• Volume:
  27
• NIOSHTIC Number:
  nn:00148761
• Citation:
  Short-term bioassays in the analysis of complex environmental mixtures III. Waters MD, ed. Environmental science research, New York: Plenum Press, 1983 Mar; 27:351-366
• CAS Registry Number:
  Benzo[a]pyrene (CAS RN 50-32-8)
• Editor(s):
  Waters MD
• Federal Fiscal Year:
  1983
• Peer Reviewed:
  False
• Source Full Name:
  Short-term bioassays in the analysis of complex environmental mixtures III
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/245706/cdc_245706_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]