Development of a method for the sampling and analysis of organotin compounds.

Details

• Personal Author:
  Damle A ; Grohse PM ; Gutknecht WF ; Homzak CA ; Ranade MB ; Tronzo C
• Description:
  A technique for sampling and analysis of organotin compounds was developed and tested. Samples were collected on a glass fiber filter/XAD-2 resin system and were then extracted with 0.1 percent by volume acetic-acid in acetonitrile. Separation of organotin species prior to measurement was accomplished using high performance liquid chromatography (HPLC) with a strong cation exchange column. The test compounds were measured using an electrothermal atomization atomic absorption spectrometer connected directly to the HPLC. Atomization was accomplished on a zirconium coated graphite tube furnace. Recovery and collection/recovery tests were performed using tetrabutyltin (1461252) (TBT), tributyltin-chloride (1461229), and tricyclohexyltin-hydroxide (13121705). These compounds were chosen as representative of the classes of organotins most important with regard to health effects or production/use volumes. Recovery tests were performed by spiking glass fiber filters and XAD-2 resin with and then extracting, separating, and measuring the compounds. Aerosols and vapors of the test compounds with the same concentration range were generated using a nebulizer system. The compounds were collected with collection systems composed of glass fiber filters and XAD-2 solvent resin tubes connected in series. Samples were extracted, separated, and measured. All recovery values exceeded 95 percent except for TBT at 0.01mg/m3 which exceeded 90 percent recovery. All collection/recovery values exceeded 90 percent. Overall method precision was 10.8 percent for TBT, 6.0 percent for tributyltin-chloride, and 6.6 percent for tricyclohexyltin-hydroxide in the 0.05 to 0.2mg/m3 concentration range. Filter samples were stable under refrigeration or freezing for up to 7 days after collection. The authors conclude that the method meets NIOSH criteria for collection/recovery efficiencies and precision over the 0.05 to 0.2mg/m3 concentration range for the test compounds. [Description provided by NIOSH]
• Content Notes:
  in NTRL, no PDF
• Subjects:
  Chemistry, Analytic Chromatography Occupational Health Safety
• Keywords:
  NIOSH-Contract; Decomposition products; Organic compounds; Analytical chemistry; Chromatographic analysis; Testing equipment; Analytical methods; Contract-210-80-0066
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Report
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DPSE - Division of Physical Sciences and Engineering
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-137
• NIOSHTIC Number:
  nn:00135706
• NTIS Accession Number:
  PB83180737
• Citation:
  NIOSH 1982 Apr; :1-137
• CAS Registry Number:
  Cyhexatin (CAS RN 13121-70-5) ; Tetrabutyltin (CAS RN 1461-25-2) ; Tributyltin chloride (CAS RN 1461-22-9)
• Federal Fiscal Year:
  1982
• Peer Reviewed:
  False
• Source Full Name:
  Division of Physical Sciences and Engineering, NIOSH, U.S. Department of Health and Human Services, Cincinnati, Ohio, NTIS PB83-180-737
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/245621/cdc_245621_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]