Details:

Alternative Title:
Environ Health Perspect
Personal Author:
Brain, J D
Description:
Pulmonary macrophages are important since their migratory patterns and behavior are often pivotal events in the pathogenesis of pulmonary disease. Alveolar macrophages act to decrease the probability of particle penetration through epithelial barriers, and their phagocytic and lytic potentials provide most of the known bactericadal properties of the lung. Macrophages are also involved in immune responses and in defense against neoplasms. Increased inert or infectious particles stimulate the recruitment of additional macrophages. Most free cells containing particles eventually reach the airways and are quickly carried to the pharynx and swallowed. In addition, evidence has now accumulated that macrophages play a part in the pathogenesis of pulmonary diseases. For example, the ingestion of some particles by macrophages causes a release of lysosomal enzymes into the macrophage cytoplasm. These enzymes may kill the macrophage, and dead or dying macrophages release a substance with attracts fibroblasts that elicit fibrogenic responses. Other toxic particles, such as cigarette smoke, my lead to a release of proteases and other toxic enzymes. All particles are capable of competitive inhibition of phagocytosis in macrophages and many may be cytotoxic and further depress phagocytosis. In addition, connective tissue macrophages may contribute to lung disease by concentrating and storing potent carcinogens or other toxic particles close to a reactive bronchial epithelium for long periods. Thus, even through macrophages serve as a first line of defense for the alveolar surface, they may also be capable of injuring the host while exercising their defensive role.
Subjects:
[+]
Air Pollutants Allergens Cell Movement Collagen Immunity, Cellular Lung Diseases Lysosomes Macrophages Peptide Hydrolases Phagocytosis Pneumoconiosis Pulmonary Alveoli Pulmonary Emphysema Sarcoidosis
Source:
Environ Health Perspect. 35:21-28.
Pubmed ID:
6997029
Pubmed Central ID:
PMC1568469
Document Type:
Journal Article
Funding:
EPA-RA05091/EP/EAPO CDC HHS/United States ; HL 19170/HL/NHLBI NIH HHS/United States
EPA-RA05091/EP/EAPO CDC HHS/United States ; HL 19170/HL/NHLBI NIH HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:a4f1a3718ad9e512dbc6abeb4de71f9829a7daabcc148582da58e369e379423e
Download URL:
https://stacks.cdc.gov/view/cdc/24526/cdc_24526_DS1.pdf
File Type:

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