Combining reproductive studies of men exposed to 2-ethoxyethanol to increase statistical power.

Details

• Personal Author:
  Ratcliffe, Jennifer M. ; Schrader, Steven M. ; Simon SD ; Turner TW ; Welch LS
• Description:
  A statistical analysis was performed on data obtained from two earlier studies in which workers had been occupationally exposed to 2-ethoxyethanol (110805) (2EE). In the first study, 37 men were evaluated who used 2EE in a metal castings company. The second study involved 40 men exposed to 2EE in a spray painting operation. The breathing zone exposure in the first study was 6.6 parts per million (ppm) (24.4mg/m3) and in the second was 2.7ppm (9.9mg/m3). In each study the men also had substantial skin exposure to 2EE. Semen analysis was conducted on each man after a requested 2 day abstinence time. Sperm concentration and semen volume indicated a significant effect of exposure to 2EE when the studies were combined, while neither of the studies individually indicated significant differences. For the parameter of sperm/ejaculate, percent normal sperm forms, curvilinear velocity of the sperm cells, and percent viability sperm by stain exclusion, the combined p-value lies between the p-values of the individual studies. The percent motility and percent viable by hypoosmotic swelling p-values decreased when the studies were combined. The authors suggest that these findings support the need to publish the data from all studies whether or not a highly significant difference is observed. Such publications would allow for combining data from complementary studies. Using a mixed model of analysis of variance with a random effect for study location, the men in these two studies exposed to 2EE had significantly lower sperm concentrations and semen volumes than men in the control populations. [Description provided by NIOSH]
• Subjects:
  Epidemiology Metal Workers Occupational Exposure Occupational Health Paint Risk Assessment Risk Factors Safety Skin Spermatogenesis Urogenital Diseases Urogenital System

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• Keywords:
  NIOSH-Author; Reproductive-hazards; Skin-exposure; Reproductive-system-disorders; Risk-factors; Epidemiology; Fertility; Occupational-exposure; Metal-workers; Painters; Spermatogenesis
• ISSN:
  1061-0251
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DBBS - Division of Biomedical and Behavioral Sciences
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  411-415
• Volume:
  2
• NIOSHTIC Number:
  nn:00234151
• Citation:
  Occup Hyg 1996 Jan; 2(1-6):411-415
• CAS Registry Number:
  Glycol monoethyl ether (CAS RN 110-80-5)
• Federal Fiscal Year:
  1996
• NORA Priority Area:
  Reproductive System Disorders
• Peer Reviewed:
  False
• Source Full Name:
  Occupational Hygiene
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/243513/cdc_243513_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]