Quinolone arthropathy in juvenile New Zealand white rabbits.

Details

• Personal Author:
  Childress CP ; Henningse GM ; Mastin JP ; Sharpnack DD
• Description:
  An animal model for the study of osteoarthritis was described. The model involved the induction of degenerative articular lesions in New-Zealand-White-rabbits by the injection of nalidixic-acid (389082) (NA). Rabbits were injected with 1,000mg/kg NA daily for 3, 7, or 14 days. Hip, stifle, elbow, and shoulder joints were examined 14 days after the last injection. Gross abnormalities included blister like projections on the surfaces of the articular cartilage and erosions; frequency was dependent upon the joint and the duration of treatment. Light microscopic findings indicated progressive damage with increasing duration of treatment and included, in various degrees of severity, clefts in articular cartilage containing collagen strands, pyknotic nuclei in necrotic chondrocytes, cartilaginous flaps, and vesicles. Histochemical changes in the cartilaginous matrices within the articular lesions were seen at all stages of lesion development. Ultramicroscopic examination confirmed and characterized the degeneration and necrosis of the chondrocytes and demonstrated a decrease in density of collagen fibers in lesion areas along with fragmented fibers. The authors conclude that the quinolone arthropathy induced in rabbits in the present study is consistent with that seen in other experimental animals and represents a good model of osteoarthritis in humans. [Description provided by NIOSH]
• Subjects:
  Hazardous Substances Laboratories Musculoskeletal Diseases Musculoskeletal System Occupational Health Safety
• Keywords:
  NIOSH-Author; Musculoskeletal-system; Carboxylic-acids; Musculoskeletal-system-disorders; Laboratory-animals; Toxic-effects; Histopathology
• ISSN:
  0023-6764
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DBBS - Division of Biomedical and Behavioral Sciences
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  436-442
• Volume:
  44
• Issue:
  5
• NIOSHTIC Number:
  nn:00226506
• Citation:
  Lab Anim Sci 1994 Oct; 44(5):436-442
• CAS Registry Number:
  Nalidixic acid (CAS RN 389-08-2)
• Federal Fiscal Year:
  1995
• NORA Priority Area:
  Disease and Injury: Musculoskeletal Disorders of the Upper Extremities
• Peer Reviewed:
  True
• Source Full Name:
  Laboratory Animal Science
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/243367/cdc_243367_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]