Molecular Epidemiology of Coxiella burnetii from Ruminants in Q Fever Outbreak, the Netherlands

Roest, Hendrik I.J.; Ruuls, Robin C.; Tilburg, Jeroen J.H.C.; Nabuurs-Franssen, Marrigje H.; Klaassen, Corné H.W.; Vellema, Piet; van den Brom, René; Dercksen, Daan; Wouda, Willem; Spierenburg, Marcel A.H.; van der Spek, Arco N.; Buijs, Rob; de Boer, Albert G.; Willemsen, Peter Th.J.; van Zijderveld, Fred G.

doi:10.3201/eid1704.101562

i

Molecular Epidemiology of Coxiella burnetii from Ruminants in Q Fever Outbreak, the Netherlands

Supporting Files Public Domain

Apr 2011
By Roest, Hendrik I.J. ; Ruuls, Robin C. ; Tilburg, Jeroen J.H.C. ; ...

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Alternative Title:

Emerg Infect Dis
Personal Author:

Roest, Hendrik I.J. ; Ruuls, Robin C. ; Tilburg, Jeroen J.H.C. ; Nabuurs-Franssen, Marrigje H. ; Klaassen, Corné H.W. ; Vellema, Piet ; van den Brom, René ; Dercksen, Daan ; Wouda, Willem ; Spierenburg, Marcel A.H. ; van der Spek, Arco N. ; Buijs, Rob ; de Boer, Albert G. ; Willemsen, Peter Th.J. ; van Zijderveld, Fred G.
Description:

Q fever is a zoonosis caused by the bacterium Coxiella burnetii. One of the largest reported outbreaks of Q fever in humans occurred in the Netherlands starting in 2007; epidemiologic investigations identified small ruminants as the source. To determine the genetic background of C. burnetii in domestic ruminants responsible for the human Q fever outbreak, we genotyped 126 C. burnetii-positive samples from ruminants by using a 10-loci multilocus variable-number tandem-repeat analyses panel and compared them with internationally known genotypes. One unique genotype predominated in dairy goat herds and 1 sheep herd in the human Q fever outbreak area in the south of the Netherlands. On the basis of 4 loci, this genotype is similar to a human genotype from the Netherlands. This finding strengthens the probability that this genotype of C. burnetii is responsible for the human Q fever epidemic in the Netherlands.
Subjects:

Animals Bacteria Bacterial Typing Techniques Cattle Coxiella Burnetii Disease Outbreaks Genotype Goat Goat Diseases Goats Humans Molecular Epidemiology Multilocus Sequence Typing Netherlands Phylogeny Q Fever Research Ruminants Sheep Sheep Diseases The Netherlands Zoonoses
Source:

Emerg Infect Dis. 17(4):668-675.
Document Type:

Journal Article
Volume:

17
Issue:

4
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:c08a63cf2290bae6e1ab20dd9d6a9837c72e39e2302ea2f9d985addecad4edfd
Download URL:

https://stacks.cdc.gov/view/cdc/24325/cdc_24325_DS1.pdf
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[PDF - 591.89 KB ]

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