Respirable particulate surface interactions with the lecithin component of pulmonary surfactant.

Details

• Personal Author:
  Hill C ; Keane M ; Mike P ; Raghootama P ; Seerha M ; Vallyathan V ; Wallace W
• Description:
  The prophylactic effect of dipalmitoyl-lecithin (DPL) adsorption to respirable quartz (14808607) and kaolin (1332587) dusts was examined so far as potential toxicity for lung cells was concerned. Fourier transform infrared spectroscopy (FTIR) and photoacoustic spectroscopy of lecithin on quartz and of lecithin on kaolin were carried out. The surface toxicity both of quartz and kaolin dusts was eliminated in short term cytotoxicity assays. Quartz was readily retoxified by phospholipase-A2 in a cell free in-vitro system and was relatively free of retained phospholipids. Kaolin was not readily retoxified at comparable enzyme levels and retained both DPL and phospholipid degradation products. The pH dependence suggested that both quartz and kaolin have acidic surface groups that are involved in hemolysis, and may also be associated with the positively charged trimethylamine group of DPL. FTIR spectra suggested that kaolin probably interacts with the phosphate group of DPL, and both quartz and kaolin probably interact with the trimethyl amine group. There may be a surface chemistry effect in the differing rates of hydrolysis by phospholipase-A2. [Description provided by NIOSH]
• Content Notes:
  in NTRL, no PDF
• Subjects:
  Air Pollutants, Occupational Dust Hazardous Substances Lung Occupational Health Particulate Matter Respiratory System Respiratory Tract Diseases Safety Surface-Active Agents
• Keywords:
  NIOSH-Author; Alveolar-cells; Respiratory-system-disorders; Airborne-particles; Toxic-effects; Surfactants; Dust-exposure; Mineral-dusts; In-vitro-studies
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Report
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-24
• NIOSHTIC Number:
  nn:00205497
• NTIS Accession Number:
  PB92176767
• Citation:
  Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, 1992 Jan; :1-24
• CAS Registry Number:
  Kaolin (CAS RN 1332-58-7) ; Quartz (SiO2) (CAS RN 14808-60-7)
• Federal Fiscal Year:
  1992
• Peer Reviewed:
  False
• Source Full Name:
  National Institute for Occupational Safety and Health
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/243126/cdc_243126_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]