The relation of polychlorinated biphenyls to birthweight and gestational age in the offspring of occupationally exposed mothers.

Details

• Personal Author:
  Lawrence CE ; Stelma J ; Taylor, Philip R.
• Description:
  A study was made of the relation between occupational exposure of women to high homolog polychlorinated biphenyls (PCB) and birthweight and gestational age among the live offspring of these workers. In 1982 interviews were conducted with 200 women who had held jobs with direct PCB exposure. A comparison was made with 205 women who had never held such a job. When all births occurring to mothers following exposure to PCBs were considered, the unadjusted mean birthweight in the direct exposure group was 96 grams less than the comparison group. No differences in gestational age were seen between groups. The birthweight difference was reduced to 41 grams following adjustment for potential confounding factors. In a parallel analysis using a continuous exposure variable estimate generated from an independently derived serum PCB prediction model, no effect of PCBs was noted on birthweight or gestational age using either crude or adjusted analyses. The authors conclude that no evidence for a biologically meaningful effect of high homolog PCBs on gestational age or birthweight exists. [Description provided by NIOSH]
• Content Notes:
  in NTRL, no PDF
• Subjects:
  Hydrocarbons Occupational Exposure Occupational Health Polychlorinated Biphenyls Safety Urogenital Diseases Urogenital System
• Keywords:
  NIOSH-Contract; Contract-210-81-5102; Reproductive-system-disorders; Reproductive-hazards; Embryotoxicity; Humans; Chlorinated-hydrocarbons; Transplacental-exposure; Occupational-exposure; Polychlorinated-biphenyls
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Final Contract Report
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-29
• NIOSHTIC Number:
  nn:00202721
• NTIS Accession Number:
  PB92133297
• Citation:
  NIOSH 1984 Sep; :1-29
• CAS Registry Number:
  1,1′-Biphenyl, chloro derivs. (CAS RN 1336-36-3)
• Federal Fiscal Year:
  1984
• NORA Priority Area:
  Disease and Injury: Fertility and Pregnancy Abnormalities
• Peer Reviewed:
  False
• Source Full Name:
  Statistical and Computer Science Laboratory, Wadsworth Center for Labs and Research, New York State Department of Health, NIOSH Contract No. 210-81-5102, 29 pages, 15 references
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/243073/cdc_243073_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]