NIOSH Testimony on Occupational Exposure to Ethylene Oxide by J. D. Millar, April 2, 1982.

Details

• Corporate Authors:
  National Institute for Occupational Safety and Health
• Description:
  In this testimony NIOSH reaffirms that ethylene-oxide (75218) (EtO) should be regarded as a potential carcinogen and that appropriate controls be used to reduce worker exposure to this compound. NIOSH has completed a study that further defines the toxicity of EtO as a consequence of chronic inhalation by rats and monkeys. Groups of Fischer 344-rats and Cynomolgus-monkeys were exposed for 7 hours a day, 5 days a week, for 24 months. One group was exposed at 50 parts per million (ppm) and the other at 100ppm EtO. Preliminary findings indicate that EtO significantly increased the frequency of chromosomal aberrations in peripheral lymphocytes of animals in both exposure groups. The prevalence of sister chromatid exchanges was also significantly increased in the exposed animals. [Description provided by NIOSH]
• Content Notes:
  in NTRL, no PDF
• Subjects:
  Carcinogens Chromosomes Hazardous Substances Laboratories Occupational Exposure Occupational Health Respiratory System Safety
• Keywords:
  NIOSH-Author; NIOSH-Testimony; Millar-J-D; Toxic-gases; Occupational-exposure; Carcinogens; Laboratory-animals; Chromosome-damage; Inhalation-studies; Genotoxic-effects
• Document Type:
  Text
• Genre:
  Testimony
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-2
• NIOSHTIC Number:
  nn:00196007
• NTIS Accession Number:
  PB91152249
• Citation:
  NIOSH 1982 Apr:2 pages
• CAS Registry Number:
  Ethylene oxide (CAS RN 75-21-8)
• Federal Fiscal Year:
  1982
• Peer Reviewed:
  False
• Source Full Name:
  NIOSH, 2 pages
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/242961/cdc_242961_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]