U.S. flag An official website of the United States government.
Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

i

Genetic susceptibility and the estimation of risk.

Public Domain


Details

  • Personal Author:
    Omenn GS
  • Description:
    Genetic susceptibility and its effect on risk assessment were discussed. The author indicates that individuals respond differently to exposures to potentially hazardous chemicals and these differences in susceptibility constitute a significant variable when evaluating the risks to their health posed by the chemicals. Differences in susceptibility can be due to factors such as genetic traits, age, sex, the presence of preexisting diseases, behavioral traits, concomitant exposures, medications and vitamins, and individual protective measures and work practices. A framework for conducting a risk assessment was outlined. It consists of a hazard identification step, a characterization step, and a control step. Genetic factors must be factored into the procedure. Preexisting genetic damage or genetic deficiencies may increase susceptibility to exogenous agents. Polygenic inheritance and genetic/environmental interactions including the role of nutrition are considered more important than single gene traits in creating host susceptibility to chemical agents. Examples of genetic predispositions to chemical agents arising from differences in metabolism and tissue sensitivity were discussed. These include the acetylator phenotype, debrisoquine metabolism polymorphism, plasma paraoxonase activity, hemolysis due to glucose-6-phosphate- dehydrogenase deficiency, and the effects of alpha-1-antitrypsin deficiency. The author concludes that recognizing individuals or groups of individuals at increased risk for adverse effects from chemical agents due to genetic or other factors is an important aspect of risk assessment and requires greater efforts to reduce or minimize exposures to such agents. [Description provided by NIOSH]
  • Subjects:
  • Keywords:
  • Document Type:
    Text
  • Genre:
    Proceedings
  • Place as Subject:
  • CIO:
    National Institute for Occupational Safety and Health (NIOSH)
  • Topic:
    Workplace Safety & Health
  • Location:
    North America
  • Pages in Document:
    1-24
  • NIOSHTIC Number:
    nn:00173356
  • Citation:
    NIOSH 1985 May; :1-24
  • Federal Fiscal Year:
    1985
  • Peer Reviewed:
    False
  • Source Full Name:
    Proceedings of a Symposium on Epidemiology and Health Risk Assessment, Columbia, Maryland, May 14-16, 1985, Centers for Disease Control/NIOSH, 24 pages, 33 references
  • Collection(s):
  • Main Document Checksum:
    urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
  • Download URL:
  • File Type:
    Filetype[PDF - 168.02 KB ]
PREVIOUS
ON THIS PAGE
Details
CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners.

As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.
BACK TO TOP