Details:

Alternative Title:
J Infect Dis
Personal Author:
Marjuki, Henju ; Mishin, Vasiliy P. ; Chesnokov, Anton P. ; De La Cruz, Juan A. ; Fry, Alicia M. ; ... More +
Marjuki, Henju ; Mishin, Vasiliy P. ; Chesnokov, Anton P. ; De La Cruz, Juan A. ; Fry, Alicia M. ; Villanueva, Julie ; Gubareva, Larisa V. Less -
Description:
Human infections caused by avian influenza A virus type subtype H7N9 have been associated with substantial morbidity and mortality. Emergence of virus variants carrying markers of decreased susceptibility to neuraminidase inhibitors was reported. Here we show that DAS181 (Fludase), an antiviral drug with sialidase activity, potently inhibited replication of wild-type influenza A(H7N9) and its oseltamivir-resistant R292K variants in mice. A once-daily administration initiated early after lethal infection hampered body weight loss and completely protected mice from lethality. We observed a time-dependent effect for 24-72-hour delayed DAS181 treatments on morbidity and mortality. The results warrant further investigation of DAS181 for influenza treatment.
Subject:
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Animals
Antiviral Agents
Drug Resistance
Drug Resistance, Viral
Fludase (DAS181)
Genetic Variation
H7N9
Influenza A Virus, H7N9 Subtype
Major Articles And Brief Reports
Mice
Neuraminidase Inhibitor
Orthomyxoviridae Infections
Oseltamivir
R292K
Recombinant Fusion Proteins
Virus Replication
Zoonoses

Source:
J Infect Dis. 2014; 210(3):435-440
Pubmed ID:
24569063
Pubmed Central ID:
PMC4091581
Document Type:
Journal Article
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:0013e5c1a043bb63f3b87b055516a6a43c4684c9ef533a9a89ae03d10f0a8f8a
File Type:

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