Final report: identification of possible causative agents in byssinosis.

Details

• Personal Author:
  Weber K
• Description:
  The final report on studies to identify possible etiological agents in byssinosis is presented. Reprints of all papers originating from the project are provided. The effects of a crude aqueous cotton bract extract (CBE) on the isolated trachealis muscle from dogs, guinea-pigs, and cats were evaluated. The CBEs induced contractions in the trachealis muscle. The active agents in the CBE were dialyzable, having molecular weights of less than 14,000. In studies of the effects of CBEs on pulmonary surface tension, ammonia removed about 90 percent of the surface active material from cotton dusts. Gossypol, a cotton metabolite, was found to be the agent probably responsible for most of the surface activity of cotton dusts. Studies with gossypol and other cotton metabolites, such as rutin and catechin, found they could compromise alveolar macrophage function, gossypol having the greatest effect and catechin the least. Studies on the effect of dimethyl-sulfoxide, acetone, ethanol, methanol, and ethyl-acetate on rabbit lung microsomal benzo(a)pyrene-hydroxylase activity were conducted to find the best solvent for pulmonary metabolism studies. Dimethyl-sulfoxide was the best solvent, and is recommended as the solvent vehicle of choice for pulmonary metabolism studies. [Description provided by NIOSH]
• Subjects:
  Environmental Monitoring Inhalation Exposure Lung Occupational Health Respiratory System Safety
• Keywords:
  NIOSH-Author; Breathing-atmospheres; Inhalants; Lung; Lung-function; Pulmonary-clearance; Air-sampling; Respiration; Pulmonary-function
• Document Type:
  Text
• Genre:
  Report
• Place as Subject:
  OSHA Region 3 ; Virginia ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-158
• NIOSHTIC Number:
  nn:00159450
• Citation:
  NIOSH 1985 Aug; :1-158
• Federal Fiscal Year:
  1985
• Peer Reviewed:
  False
• Source Full Name:
  NIOSH, U.S. Department of Health and Human Services, Morgantown, West Virginia, 158 pages, 152 references
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/242170/cdc_242170_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]