Changes in Capsule and Drug Resistance of Pneumococci after Introduction of PCV7, Japan, 2010–2013

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Chiba, Naoko ; Morozumi, Miyuki ; Shouji, Michi ; Wajima, Takeaki ; Iwata, Satoshi ; Ubukata, Kimiko
• Corporate Authors:
  Invasive Pneumococcal Diseases Surveillance Study Group
• Description:
  We aimed to clarify changes in serotypes and genotypes mediating β-lactam and macrolide resistance in Streptococcus pneumoniae isolates from Japanese children who had invasive pneumococcal disease (IPD) after the 7-valent pneumococcal conjugate vaccine (PCV7) was introduced into Japan; 341 participating general hospitals conducted IPD surveillance during April 2010-March 2013. A total of 300 pneumococcal isolates were collected in 2010, 146 in 2011, and 156 in 2012. The proportion of vaccine serotypes in infectious isolates decreased from 73.3% to 54.8% to 14.7% during the 3 years. Among vaccine serotype strains, genotypic penicillin-resistant S. pneumoniae strains also declined each year. Among nonvaccine serotype strains, 19A, 15A, 15B, 15C, and 24 increased in 2012. Increases were noted especially in genotypic penicillin-resistant S. pneumoniae isolates of serotypes 15A and 35B, as well as macrolide resistance mediated by the erm(B) gene in 15A, 15B, 15C, and 24.
• Subjects:
  Anti-Bacterial Agents Beta-Lactam Resistance Child Child, Preschool Drug Resistance, Bacterial Genotype Heptavalent Pneumococcal Conjugate Vaccine Humans Infant Macrolides Penicillins Pneumococcal Infections Serotyping Streptococcus Pneumoniae

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• Source:
  Emerg Infect Dis. 20(7):1132-1139.
• Document Type:
  Journal Article
• Place as Subject:
  Japan
• Location:
  Asia
• Volume:
  20
• Issue:
  7
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:3e69f80098e355a3e4c86345878872266a5b71e1003ed4b49f1345869575e01b
• Download URL:
  https://stacks.cdc.gov/view/cdc/24101/cdc_24101_DS1.pdf
• File Type:
  [PDF - 607.04 KB ]