Details:

Alternative Title:
Emerg Infect Dis
Publisher's site:
http://dx.doi.org/10.3201/eid2007.131485
Personal Author:
Chiba, Naoko; Morozumi, Miyuki; Shouji, Michi; Wajima, Takeaki; Iwata, Satoshi; ... More +
Chiba, Naoko; Morozumi, Miyuki; Shouji, Michi; Wajima, Takeaki; Iwata, Satoshi; Ubukata, Kimiko; Less -
Corporate Authors:
Invasive Pneumococcal Diseases Surveillance Study Group;
Description:
We aimed to clarify changes in serotypes and genotypes mediating β-lactam and macrolide resistance in Streptococcus pneumoniae isolates from Japanese children who had invasive pneumococcal disease (IPD) after the 7-valent pneumococcal conjugate vaccine (PCV7) was introduced into Japan; 341 participating general hospitals conducted IPD surveillance during April 2010-March 2013. A total of 300 pneumococcal isolates were collected in 2010, 146 in 2011, and 156 in 2012. The proportion of vaccine serotypes in infectious isolates decreased from 73.3% to 54.8% to 14.7% during the 3 years. Among vaccine serotype strains, genotypic penicillin-resistant S. pneumoniae strains also declined each year. Among nonvaccine serotype strains, 19A, 15A, 15B, 15C, and 24 increased in 2012. Increases were noted especially in genotypic penicillin-resistant S. pneumoniae isolates of serotypes 15A and 35B, as well as macrolide resistance mediated by the erm(B) gene in 15A, 15B, 15C, and 24.
Subject:
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Anti-Bacterial Agents
Beta-Lactam Resistance
Child
Child, Preschool
Drug Resistance, Bacterial
Genotype
Heptavalent Pneumococcal Conjugate Vaccine
Humans
Infant
Macrolides
Penicillins
Pneumococcal Infections
Serotyping
Streptococcus Pneumoniae

Source:
Emerg Infect Dis. 20(7):1132-1139.;
Document Type:
Journal Article;
Place as Subject:
Japan;
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:3e69f80098e355a3e4c86345878872266a5b71e1003ed4b49f1345869575e01b
File Type:

Supporting Files

• 	13-1485.nxml	txt
  	license.txt	txt
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