Changes in Capsule and Drug Resistance of Pneumococci after Introduction of PCV7, Japan, 2010–2013

Chiba, Naoko; Morozumi, Miyuki; Shouji, Michi; Wajima, Takeaki; Iwata, Satoshi; Ubukata, Kimiko

doi:10.3201/eid2007.131485

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Changes in Capsule and Drug Resistance of Pneumococci after Introduction of PCV7, Japan, 2010–2013

Published Date:

Jul 2014

Publisher's site:

http://dx.doi.org/10.3201/eid2007.131485 New Site Icon

Source:

Emerg Infect Dis. 20(7):1132-1139.

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Details:

Alternative Title:

Emerg Infect Dis

Personal Author:

Chiba, Naoko ; Morozumi, Miyuki ; Shouji, Michi ; Wajima, Takeaki ; Iwata, Satoshi ; ... More ▼

Corporate Authors:

Invasive Pneumococcal Diseases Surveillance Study Group

Description:

We aimed to clarify changes in serotypes and genotypes mediating β-lactam and macrolide resistance in Streptococcus pneumoniae isolates from Japanese children who had invasive pneumococcal disease (IPD) after the 7-valent pneumococcal conjugate vaccine (PCV7) was introduced into Japan; 341 participating general hospitals conducted IPD surveillance during April 2010-March 2013. A total of 300 pneumococcal isolates were collected in 2010, 146 in 2011, and 156 in 2012. The proportion of vaccine serotypes in infectious isolates decreased from 73.3% to 54.8% to 14.7% during the 3 years. Among vaccine serotype strains, genotypic penicillin-resistant S. pneumoniae strains also declined each year. Among nonvaccine serotype strains, 19A, 15A, 15B, 15C, and 24 increased in 2012. Increases were noted especially in genotypic penicillin-resistant S. pneumoniae isolates of serotypes 15A and 35B, as well as macrolide resistance mediated by the erm(B) gene in 15A, 15B, 15C, and 24.

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Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases

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