Cellular transformations.

Details

• Personal Author:
  Kuschner M
• Description:
  Cellular transformations are discussed in relation to occupational carcinogenesis and experimental medicine. The use of animal models in cancer research, particularly in studies of inhalation cancer, is reviewed. The irritative effects of sulfite (14265453) in carcinoma production are noted, emphasizing the increased incidence of cancer among coke oven operators and workers exposed to roofing tar. Hexavalent-chromium (18540299) as calcium-chromate (13765190) is cited as the source of a 10 fold increase in the incidence of lung cancer in chromate workers. Ionizing radiation from radon and radon daughters is identified as the cause of lung cancer in uranium mine workers. A dose effect for ionizing radiation is shown to be experimentally validated. The effects of industrial byproducts on the general population are reconsidered. The author suggests that the microenvironment created by the individual for himself is a major characteristic in cancer induction. [Description provided by NIOSH]
• Subjects:
  Carcinogens Epidemiology Hazardous Substances Laboratories Occupational Health Radiation Safety
• Keywords:
  NIOSH-Contract; Contract-210-78-0053; Carcinogenesis; Occupational-health; Epidemiology; Toxic-substances; Cell-alteration; Radiation-effects; Humans; Laboratory-animals
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Proceedings
• Place as Subject:
  Arizona ; Ohio ; OSHA Region 5 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DTS - Division of Technical Services
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  108-110
• NIOSHTIC Number:
  nn:00091707
• Citation:
  NIOSH 1979 Jun; :108-110
• CAS Registry Number:
  Calcium chromate (CAS RN 13765-19-0) ; Chromium(6+) (CAS RN 18540-29-9) ; Sulfite (CAS RN 14265-45-3)
• Federal Fiscal Year:
  1979
• Peer Reviewed:
  False
• Source Full Name:
  Occupational Safety and Health Symposia 1978, Division of Technical Services, NIOSH, Cincinnati, Ohio
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dc847c09aedf140bc731323e8446b4703641ae07d6ad9e7b7238120dab30b8f7dcaa9b938d34d035f87873a0fe7fec262d5d13dcaf290925445e82b6de3b57d
• Download URL:
  https://stacks.cdc.gov/view/cdc/240900/cdc_240900_DS1.pdf
• File Type:
  [PDF - 168.02 KB ]