Risk of lymphoma subtypes after solid organ transplantation in the United States

Details

• Alternative Title:
  Br J Cancer
• Personal Author:
  Clarke, C A ; Morton, L M ; Lynch, C ; Pfeiffer, R M ; Hall, E C ; Gibson, T M ; Weisenburger, D D ; Martínez-Maza, O ; Hussain, S K ; Yang, J ; Chang, E T ; Engels, E A
• Description:
  Background:
  
  Solid organ transplant recipients have high risk of lymphomas, including non-Hodgkin lymphoma (NHL) and Hodgkin lymphoma (HL). A gap in our understanding of post-transplant lymphomas involves the spectrum and associated risks of their many histologic subtypes.
  
  Methods:
  
  We linked nationwide data on solid organ transplants from the US Scientific Registry of Transplant Recipients (1987–2008) to 14 state and regional cancer registries, yielding 791 281 person-years of follow-up for 19 distinct NHL subtypes and HL. We calculated standardised incidence ratios (SIRs) and used Poisson regression to compare SIRs by recipient age, transplanted organ, and time since transplantation.
  
  Results:
  
  The risk varied widely across subtypes, with strong elevations (SIRs 10–100) for hepatosplenic T-cell lymphoma, Burkitt's lymphoma, NK/T-cell lymphoma, diffuse large B-cell lymphoma, and anaplastic large-cell lymphoma (both systemic and primary cutaneous forms). Moderate elevations (SIRs 2–4) were observed for HL and lymphoplasmacytic, peripheral T-cell, and marginal zone lymphomas, but SIRs for indolent lymphoma subtypes were not elevated. Generally, SIRs were highest for younger recipients (<20 years) and those receiving organs other than kidneys.
  
  Conclusion:
  
  Transplant recipients experience markedly elevated risk of a distinct spectrum of lymphoma subtypes. These findings support the aetiologic relevance of immunosuppression for certain subtypes and underscore the importance of detailed haematopathologic workup for transplant recipients with suspected lymphoma.
  
  
• Subjects:
  Adolescent Adult Aged Aged, 80 And Over Child Child, Preschool Epidemiology Female Humans Incidence Infant Lymphoma Male Middle Aged Organ Transplantation Registries Risk Factors Treatment Outcome Young Adult

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• Source:
  Br J Cancer. 2013; 109(1):280-288.
• Pubmed ID:
  23756857
• Pubmed Central ID:
  PMC3708563
• Document Type:
  Journal Article
• Funding:
  1U58 DP000807-01/DP/NCCDPHP CDC HHS/United States ; 5658DP000805-04/DP/NCCDPHP CDC HHS/United States ; 5U58/DP000808-05/DP/NCCDPHP CDC HHS/United States ; 5U58DP000812-03/DP/NCCDPHP CDC HHS/United States ; 5U58DP000817-05/DP/NCCDPHP CDC HHS/United States ; 5U58DP000824-04/DP/NCCDPHP CDC HHS/United States ; HHSH234200537009C/PHS HHS/United States ; HHSH250201000018C/PHS HHS/United States ; HHSN261201000024C/PHS HHS/United States ; HHSN261201000026C/PHS HHS/United States ; HHSN261201000027C/PHS HHS/United States ; HHSN261201000032C/PHS HHS/United States ; HHSN261201000034C/PHS HHS/United States ; HHSN261201000035C/PHS HHS/United States ; HHSN261201000037C/PHS HHS/United States ; HHSN261201000040C/PHS HHS/United States ; K07 CA140360/CA/NCI NIH HHS/United States ; N01-PC-35137/PC/NCI NIH HHS/United States ; N01-PC-35139/PC/NCI NIH HHS/United States ; N01-PC-35142/PC/NCI NIH HHS/United States ; N01-PC-35143/PC/NCI NIH HHS/United States ; N01-PC-54405/PC/NCI NIH HHS/United States ; U58DP000832/DP/NCCDPHP CDC HHS/United States ; U58DP000848-04/DP/NCCDPHP CDC HHS/United States
• Place as Subject:
  United States
• Volume:
  109
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:a19c9ce305fa551e0e68e6fadb40cd6c250e219c833e9b4b69356f8da7ae0e85
• Download URL:
  https://stacks.cdc.gov/view/cdc/24076/cdc_24076_DS1.pdf
• File Type:
  [PDF - 182.41 KB ]