Details:

Alternative Title:
Br J Cancer
Publisher's site:
http://dx.doi.org/10.1038/bjc.2013.294
Personal Author:
Clarke, C A ; Morton, L M ; Lynch, C ; Pfeiffer, R M ; Hall, E C ; ... More +
Clarke, C A ; Morton, L M ; Lynch, C ; Pfeiffer, R M ; Hall, E C ; Gibson, T M ; Weisenburger, D D ; Martínez-Maza, O ; Hussain, S K ; Yang, J ; Chang, E T ; Engels, E A Less -
Description:
Background:

Solid organ transplant recipients have high risk of lymphomas, including non-Hodgkin lymphoma (NHL) and Hodgkin lymphoma (HL). A gap in our understanding of post-transplant lymphomas involves the spectrum and associated risks of their many histologic subtypes.

Methods:

We linked nationwide data on solid organ transplants from the US Scientific Registry of Transplant Recipients (1987–2008) to 14 state and regional cancer registries, yielding 791 281 person-years of follow-up for 19 distinct NHL subtypes and HL. We calculated standardised incidence ratios (SIRs) and used Poisson regression to compare SIRs by recipient age, transplanted organ, and time since transplantation.

Results:

The risk varied widely across subtypes, with strong elevations (SIRs 10–100) for hepatosplenic T-cell lymphoma, Burkitt's lymphoma, NK/T-cell lymphoma, diffuse large B-cell lymphoma, and anaplastic large-cell lymphoma (both systemic and primary cutaneous forms). Moderate elevations (SIRs 2–4) were observed for HL and lymphoplasmacytic, peripheral T-cell, and marginal zone lymphomas, but SIRs for indolent lymphoma subtypes were not elevated. Generally, SIRs were highest for younger recipients (<20 years) and those receiving organs other than kidneys.

Conclusion:

Transplant recipients experience markedly elevated risk of a distinct spectrum of lymphoma subtypes. These findings support the aetiologic relevance of immunosuppression for certain subtypes and underscore the importance of detailed haematopathologic workup for transplant recipients with suspected lymphoma.


Subject:
[+]
Adolescent
Adult
Aged
Aged, 80 And Over
Child
Child, Preschool
Epidemiology
Female
Humans
Incidence
Infant
Lymphoma
Male
Middle Aged
Organ Transplantation
Registries
Risk Factors
Treatment Outcome
Young Adult

Source:
Br J Cancer. 2013; 109(1):280-288.
Pubmed ID:
23756857
Pubmed Central ID:
PMC3708563
Document Type:
Journal Article
Funding:
1U58 DP000807-01/DP/NCCDPHP CDC HHS/United States ; 5658DP000805-04/DP/NCCDPHP CDC HHS/United States ; 5U58/DP000808-05/DP/NCCDPHP CDC HHS/United States ; 5U58DP000812-03/DP/NCCDPHP CDC HHS/United States ; 5U58DP000817-05/DP/NCCDPHP CDC HHS/United States ; ... More +
1U58 DP000807-01/DP/NCCDPHP CDC HHS/United States ; 5658DP000805-04/DP/NCCDPHP CDC HHS/United States ; 5U58/DP000808-05/DP/NCCDPHP CDC HHS/United States ; 5U58DP000812-03/DP/NCCDPHP CDC HHS/United States ; 5U58DP000817-05/DP/NCCDPHP CDC HHS/United States ; 5U58DP000824-04/DP/NCCDPHP CDC HHS/United States ; HHSH234200537009C/PHS HHS/United States ; HHSH250201000018C/PHS HHS/United States ; HHSN261201000024C/PHS HHS/United States ; HHSN261201000026C/PHS HHS/United States ; HHSN261201000027C/PHS HHS/United States ; HHSN261201000032C/PHS HHS/United States ; HHSN261201000034C/PHS HHS/United States ; HHSN261201000035C/PHS HHS/United States ; HHSN261201000037C/PHS HHS/United States ; HHSN261201000040C/PHS HHS/United States ; K07 CA140360/CA/NCI NIH HHS/United States ; N01-PC-35137/PC/NCI NIH HHS/United States ; N01-PC-35139/PC/NCI NIH HHS/United States ; N01-PC-35142/PC/NCI NIH HHS/United States ; N01-PC-35143/PC/NCI NIH HHS/United States ; N01-PC-54405/PC/NCI NIH HHS/United States ; U58DP000832/DP/NCCDPHP CDC HHS/United States ; U58DP000848-04/DP/NCCDPHP CDC HHS/United States Less -
Place as Subject:
United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:a19c9ce305fa551e0e68e6fadb40cd6c250e219c833e9b4b69356f8da7ae0e85
File Type:

Supporting Files

• 	bjc2013294a.nxml	txt
  	license.txt	txt

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