Details:

Alternative Title:
Emerg Infect Dis
Publisher's site:
http://dx.doi.org/10.3201/eid1803.111236
Personal Author:
Chase-Topping, Margo E. ; Rosser, Tracy ; Allison, Lesley J. ; Courcier, Emily ; Evans, Judith ; ... More +
Chase-Topping, Margo E. ; Rosser, Tracy ; Allison, Lesley J. ; Courcier, Emily ; Evans, Judith ; McKendrick, Iain J. ; Pearce, Michael C. ; Handel, Ian ; Caprioli, Alfredo ; Karch, Helge ; Hanson, Mary F. ; Pollock, Kevin G.J. ; Locking, Mary E. ; Woolhouse, Mark E.J. ; Matthews, Louise ; Low, J. Chris ; Gally, David L. Less -
Description:
Escherichia coli O26 and O157 have similar overall prevalences in cattle in Scotland, but in humans, Shiga toxin-producing E. coli O26 infections are fewer and clinically less severe than E. coli O157 infections. To investigate this discrepancy, we genotyped E. coli O26 isolates from cattle and humans in Scotland and continental Europe. The genetic background of some strains from Scotland was closely related to that of strains causing severe infections in Europe. Nonmetric multidimensional scaling found an association between hemolytic uremic syndrome (HUS) and multilocus sequence type 21 strains and confirmed the role of stx(2) in severe human disease. Although the prevalences of E. coli O26 and O157 on cattle farms in Scotland are equivalent, prevalence of more virulent strains is low, reducing human infection risk. However, new data on E. coli O26-associated HUS in humans highlight the need for surveillance of non-O157 enterohemorrhagic E. coli and for understanding stx(2) phage acquisition.
Subject:
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Animals
Bacteria
Cattle
Cattle Diseases
Escherichia Coli Infections
Escherichia Coli O26
Escherichia Coli O157
Humans
MLST
Multilocus Sequence Typing
NMS
Nonmetric Multidimensional Scaling
PFGE
Prevalence
Pulsed-field Gel Electrophoresis
Research
Scotland
Shiga-Toxigenic Escherichia Coli
Shiga Toxins
Virulence Factors
Prevalence

Source:
Emerg Infect Dis. 18(3):439-448.
Document Type:
Journal Article
Funding:
095831/Wellcome Trust/United Kingdom ; Biotechnology and Biological Sciences Research Council/United Kingdom ; Wellcome Trust/United Kingdom
095831/Wellcome Trust/United Kingdom ; Biotechnology and Biological Sciences Research Council/United Kingdom ; Wellcome Trust/United Kingdom Less -
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:deb0411c6586347367e51c6ac4f869301065b696f825104747f89925d553c773
File Type:

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