Details:

Alternative Title:
Emerg Infect Dis
Publisher's site:
http://dx.doi.org/10.3201/eid1801.110725
Personal Author:
Nielsen, Alex Christian Yde; Böttiger, Blenda; Banner, Jytte; Hoffmann, Thomas; Nielsen, Lars Peter;
Nielsen, Alex Christian Yde; Böttiger, Blenda; Banner, Jytte; Hoffmann, Thomas; Nielsen, Lars Peter; Less -
Description:
The first human virus in the genus Cardiovirus was described in 2007 and named Saffold virus (SAFV). Cardioviruses can cause severe infections of the myocardium and central nervous system in animals, but SAFV has not yet been convincingly associated with disease in humans. To study a possible association between SAFV and infections in the human central nervous system, we designed a real-time PCR for SAFV and tested cerebrospinal fluid (CSF) samples from children <4 years of age. SAFV was detected in 2 children: in the CSF and a fecal sample from 1 child with monosymptomatic ataxia caused by cerebellitis; and in the CSF, blood, and myocardium of another child who died suddenly with no history of illness. Virus from each child was sequenced and shown to be SAFV type 2. These findings demonstrate that SAFV can cause serious invasive infection in children.
Subject:
[+]
Cardiovirus
Cardiovirus Infections
Central Nervous System Infections
Cerebrospinal Fluid
Child, Preschool
Children
Denmark
Encephalitis
Fatal Outcome
Feces
Female
Genome, Viral
Humans
Infant
Male
Phylogeny
Picornavirus Infections
Real-Time Polymerase Chain Reaction
Research
Saffold Virus
Viral Encephalitis
Viruses
Fatal Outcome

Source:
Emerg Infect Dis. 18(1):7-12.;
Document Type:
Journal Article;
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:aa5323f14dfaead463fe251f035ed87565e30cc71b41737d559be142c3225c62
File Type:

Supporting Files

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  	11-0725_finalR.nxml	txt
  	license.txt	txt

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